Robert Arnes-Benito
Wellcome Trust/Cancer Research UK Gurdon Institute
7 Papers
13 Citations
Robert Arnes-Benito is an academic researcher from Wellcome Trust/Cancer Research UK Gurdon Institute. The author has contributed to research in topics: Liver cancer & Wnt signaling pathway. The author has an hindex of 2, co-authored 3 publications. Previous affiliations of Robert Arnes-Benito include Max Planck Society & University of Cambridge.
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Papers
Human primary liver cancer–derived organoid cultures for disease modeling and drug screening
Laura Broutier,Gianmarco Mastrogiovanni,Monique M A Verstegen,Hayley E. Francies,Lena Morrill Gavarró,Charles R. Bradshaw,George E. Allen,Robert Arnes-Benito,Olga Sidorova,Marcia P. Gaspersz,Nikitas Georgakopoulos,Bon-Kyoung Koo,Sabine Dietmann,Susan E. Davies,Raaj K. Praseedom,Ruby Lieshout,Jan N. M. IJzermans,Stephen J. Wigmore,Kourosh Saeb-Parsy,Mathew J. Garnett,Luc J. W. van der Laan,Meritxell Huch +21 more
TL;DR: The wide-ranging biomedical utilities of PLC-derived organoid models in furthering the understanding of liver cancer biology and in developing personalized-medicine approaches for the disease are demonstrated.
Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids.
Nikitas Georgakopoulos,Nicole Prior,Nicole Prior,Brigitte Angres,Gianmarco Mastrogiovanni,Alex Cagan,Daisy Harrison,Christopher J. Hindley,Christopher J. Hindley,Robert Arnes-Benito,Robert Arnes-Benito,Siong-Seng Liau,Abbie Curd,Natasha Ivory,Benjamin D. Simons,Benjamin D. Simons,Inigo Martincorena,Helmut Wurst,Kourosh Saeb-Parsy,Meritxell Huch,Meritxell Huch +20 more
TL;DR: HPOs represent an abundant source of pancreas ductal cells that retain the characteristics of the tissue-of-origin, which opens up avenues for modelling diseases of the ductal epithelium and increasing understanding of human Pancreas exocrine biology.
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RNF43/ZNRF3 loss predisposes to hepatocellular-carcinoma by impairing liver regeneration and altering the liver lipid metabolic ground-state
German Belenguer,Gianmarco Mastrogiovanni,Clare Pacini,Zoe Hall,Anna M Dowbaj,Robert Arnes-Benito,Aleksandra Sljukic,Nicole Prior,Sofia Kakava,Charles R. Bradshaw,Susan E. Davies,Michele Vacca,Kourosh Saeb-Parsy,Bon-Kyoung Koo,Meritxell Huch +14 more
TL;DR: In this paper , the authors showed that Rnf43/Znrf3 deletion results in defective hepatocyte regeneration and liver cancer, caused by an imbalance between differentiation/proliferation.
Loss of RNF43/ZNRF3 predisposes to Hepatocellular carcinoma by impairing liver regeneration and altering liver fat metabolism
Gianmarco Mastrogiovanni,Clare Pacini,Clare Pacini,Sofia Kakava,Robert Arnes-Benito,Charles R. Bradshaw,Susan E. Davies,Kourosh Saeb-Parsy,Bon-Kyoung Koo,Bon-Kyoung Koo,Meritxell Huch +10 more
TL;DR: It is described that hepatocyte-specific deletion of both Rnf43/Znrf3 results in altered lipid metabolism and a non-alcoholic steatohepatitis (NASH) phenotype in mouse, in the absence of exogenous fat supplementation.
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Transcriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma
Amaya López-Pascual,Jasmin Elurbide,Emiliana Valbuena-Goiricelaya,M. Latasa,Elena Anaya,Elena Adán-Villaescusa,Borja Castelló-Uribe,Luz Andrea Martínez-Pérez,I. Uriarte,María Arechederra,Sergio Ciordia,Fernando Corrales,Sona Frankova,Eva Sticová,Ondřej Fabián,Leticia Colyn,Patricia Inacio,Robert Arnes-Benito,Juan Bayo,Meritxell Huch,Carmen Berasain,Maite G. Fernandez-Barrena,Matías A. Avila +22 more