Robert A. Rollins
Columbia University
5 Papers
7 Citations
Robert A. Rollins is an academic researcher from Columbia University. The author has contributed to research in topics: DNA methylation & CpG site. The author has an hindex of 4, co-authored 5 publications.
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Papers
Computational prediction of methylation status in human genomic sequences
Rajdeep Das,Nevenka Dimitrova,Zhenyu Xuan,Robert A. Rollins,Fatemah Haghighi,John R. Edwards,Jingyue Ju,Timothy H. Bestor,Michael Q. Zhang +8 more
TL;DR: A computational pattern recognition method that is used to predict the methylation landscape of human brain DNA and can be applied both to CpG islands and to non-CpG island regions is described.
Methylation Abnormalities in Mammary Carcinoma: The Methylation Suicide Hypothesis.
Anne H. O’Donnell,John R. Edwards,Robert A. Rollins,Nathan D. Vander Kraats,Tao Su,Hanina Hibshoosh,Timothy H. Bestor +6 more
TL;DR: A hypothesis under which the demethylation commonly observed in carcinomas is a manifestation of a defensive system that kills incipient cancer cells is put forward.
7 Inheritance of Genomic Methylation Patterns
TL;DR: The mammalian genome bears heritable patterns of 5-methylcytosine, most of which is within transposons, tandem repeat sequences, and CpG islands of genes subject to X inactivation.
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Chromatin and sequence features that define the fine and gross structure of genomic methylation patterns
John R. Edwards,Anne H. O'Donnell,Robert A. Rollins,Heather E. Peckham,Clarence Lee,Maria H. Milekic,Benjamin Chanrion,Yutao Fu,Tao Su,Hanina Hibshoosh,Jay A. Gingrich,Fatemeh Haghighi,Robert C. Nutter,Timothy H. Bestor +13 more
TL;DR: It is concluded that methylation is the default state of most CpG dinucleotides in the mammalian genome and that a combination of local dinucleotide frequencies, the interaction of repeated sequences, and the presence or absence of histone variants or modifications shields a population of C pG sites from DNA methyltransferases that lack intrinsic sequence specificity.
Large-scale structure of genomic methylation patterns
Robert A. Rollins,Fatemeh Haghighi,John R. Edwards,Rajdeep Das,Michael Q. Zhang,Jingyue Ju,Timothy H. Bestor +6 more
TL;DR: The enrichment of Regulatory sequences in the relatively small unmethylated compartment suggests that cytosine methylation constrains the effective size of the genome through the selective exposure of regulatory sequences.