Rob Moccia
Harvard University
6 Papers
13 Citations
Rob Moccia is an academic researcher from Harvard University. The author has contributed to research in topics: Biology & C9orf72. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Rob Moccia include Howard Hughes Medical Institute & Broad Institute.
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Papers
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair
Joseph R. Klim,Luis A. Williams,Francesco Limone,Irune Guerra San Juan,Brandi N. Davis-Dusenbery,Daniel A. Mordes,Aaron Burberry,Michael J. Steinbaugh,Kanchana K. Gamage,Rory Kirchner,Rob Moccia,Seth H. Cassel,Kuchuan Chen,Brian J. Wainger,Brian J. Wainger,Clifford J. Woolf,Kevin Eggan +16 more
TL;DR: In this paper, the authors report transcripts whose abundances in human motor neurons are sensitive to TDP-43 depletion, and they propose that restoring STMN2 expression warrants examination as a therapeutic strategy for ALS.
Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.
Evangelos Kiskinis,Evangelos Kiskinis,Evangelos Kiskinis,Jackson Sandoe,Jackson Sandoe,Jackson Sandoe,Luis A. Williams,Luis A. Williams,Luis A. Williams,Gabriella L. Boulting,Gabriella L. Boulting,Rob Moccia,Rob Moccia,Rob Moccia,Brian J. Wainger,Brian J. Wainger,Steve S.W. Han,Steve S.W. Han,Steve S.W. Han,Theodore Peng,Theodore Peng,Theodore Peng,Sebastian Thams,Shravani Mikkilineni,Shravani Mikkilineni,Shravani Mikkilineni,Cassidy Mellin,Florian T. Merkle,Florian T. Merkle,Florian T. Merkle,Brandi N. Davis-Dusenbery,Brandi N. Davis-Dusenbery,Brandi N. Davis-Dusenbery,Michael J. Ziller,Derek H. Oakley,Justin K. Ichida,Justin K. Ichida,Stefania Di Costanzo,Stefania Di Costanzo,Nick Atwater,Nick Atwater,Nick Atwater,Morgan L. Maeder,Mathew J. Goodwin,James Nemesh,James Nemesh,James Nemesh,Robert E. Handsaker,Robert E. Handsaker,Robert E. Handsaker,Daniel Paull,Scott Noggle,Steven A. McCarroll,Steven A. McCarroll,Steven A. McCarroll,J. Keith Joung,Clifford J. Woolf,Robert H. Brown,Kevin Eggan,Kevin Eggan,Kevin Eggan +60 more
TL;DR: Reprogramming and stem cell differentiation approaches with genome engineering and RNA sequencing are combined to define the transcriptional and functional changes that are induced in human motor neurons by mutant SOD1, indicating that at least a subset of these changes are more broadly conserved in ALS.
460
Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease
Aaron Burberry,Aaron Burberry,Naoki Suzuki,Naoki Suzuki,Jin Yuan Wang,Jin Yuan Wang,Rob Moccia,Rob Moccia,Daniel A. Mordes,Daniel A. Mordes,Morag Stewart,Morag Stewart,Satomi Suzuki-Uematsu,Satomi Suzuki-Uematsu,Sulagna Ghosh,Sulagna Ghosh,Ajay K. Singh,Ajay K. Singh,Florian T. Merkle,Florian T. Merkle,Kathryn Koszka,Kathryn Koszka,Quan Zhen Li,Leonard I. Zon,Derrick J. Rossi,Derrick J. Rossi,Jennifer J. Trowbridge,Luigi D. Notarangelo,Luigi D. Notarangelo,Kevin Eggan,Kevin Eggan +30 more
TL;DR: It is shown that mice harboring loss-of-function mutations in the ortholog of C9ORF72 develop splenomegaly, neutrophilia, thrombocytopenia, increased expression of inflammatory cytokines, and severe autoimmunity, ultimately leading to a high mortality rate.
256
Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients.
Daniel A. Mordes,Mercedes Prudencio,Lindsey D. Goodman,Joseph R. Klim,Joseph R. Klim,Rob Moccia,Francesco Limone,Francesco Limone,Olli Pietilainen,Olli Pietilainen,Kaitavjeet Chowdhary,Dennis W. Dickson,Rosa Rademakers,Nancy M. Bonini,Leonard Petrucelli,Kevin Eggan,Kevin Eggan +16 more
TL;DR: The results suggest that the expression of DPRs are associated with upregulation of HSF1 and activation of a heat shock response in C9ORF72-ALS/FTLD patients.
Erratum: Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1 (Cell Stem Cell (2014) 14 (781795))
Evangelos Kiskinis,Jackson Sandoe,Luis A. Williams,Gabriella L. Boulting,Rob Moccia,Brian J. Wainger,Steve S.W. Han,Theodore Peng,Sebastian Thams,Shravani Mikkilineni,Cassidy Mellin,Florian T. Merkle,Brandi N. Davis-Dusenbery,Michael J. Ziller,Derek H. Oakley,Justin K. Ichida,Stefania Di Costanzo,Nick Atwater,Morgan L. Maeder,Mathew J. Goodwin,James Nemesh,Robert E. Handsaker,Daniel Paull,Scott Noggle,Steven A. McCarroll,J. Keith Joung,Clifford J. Woolf,Robert H. Brown,Kevin Eggan +28 more
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