Rob Maher
Novartis
7 Papers
2 Citations
Rob Maher is an academic researcher from Novartis. The author has contributed to research in topics: Ubiquitin ligase & Biology. The author has an hindex of 3, co-authored 4 publications.
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Papers
Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy
Christoph Potting,Christophe Crochemore,Francesca Moretti,Florian Nigsch,Isabel Schmidt,Carole Manneville,Walter Carbone,Judith Knehr,Rowena DeJesus,Alicia Lindeman,Rob Maher,Carsten Russ,Gregory McAllister,John S. Reece-Hoyes,Gregory R. Hoffman,Guglielmo Roma,Matthias Müller,Andreas W. Sailer,Stephen B. Helliwell +18 more
TL;DR: The critical role of PARKIN abundance is demonstrated, the identified genes negatively regulate PARKIN gene expression are identified, and a link between transcriptional repression and mitophagy is revealed, which is also apparent in human induced pluripotent stem cell-derived neurons, a disease-relevant cell type.
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Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings
Martin Schröder,Martin Renatus,Xiaoyou Liang,Fabian Meili,Thomas Zoller,Sandrine Ferrand,François Gauter,Frederic Sigoillot,Scott Gleim,Jason R. Thomas,Damien Begue,Rita Andraos-Rey,BoYee Chung,Seth Carbonneau,Benika J. Pinch,Andreas Hofmann,Markus Schirle,Patricia Imbach,Delphine Gorses,Keith Calkins,Beatrice Bauer-Probst,Matthew J. Niederst,Rob Maher,Martin Henault,John Alford,Erik Ahrne,Gregory John Hollingworth,Nicolas H. Thomä,Anna Vulpetti,Thomas Radimerski,Philipp Holzer,Claudio R. Thoma +31 more
TL;DR: In this article , the essential E3 ligase receptor DCAF1 can be harnessed for targeted protein degradation (TPD) utilizing a potent, non-covalent DCAF 1 binder.
A novel HERC4-dependent glue degrader targeting STING
Merve Mutlu,Isabel Schmidt,Andrew I. Morrison,H. Goretzki,Felix Freuler,Damien Begue,Nicolas Pythoud,Erik Ahrne,Sandra Kapps,Susan Roest,Debora Bonenfant,Delphine Jeanpierre,Thi-Thanh Thao Tran,Rob Maher,Shaojian An,Amandine Rietsch,Florian Nigsch,Andreas Hofmann,John S. Reece-Hoyes,Christian N. Parker,Danilo Guerini +20 more
TL;DR: In this paper , the authors identified AK59 as a molecular glue degrader for STING and showed that the compound-induced degradation of STING by AK59 is compromised by the loss of HECT and RLD domain containing E3 ubiquitin protein ligase 4 (HERC4), ubiquitIN-like modifier activating enzyme 5 (UBA5) and UBA6, while HERC4 is the main E3 ligase for the observed degradation mechanism.
TRRAP is a central regulator of human multiciliated cell formation.
Zhao Wang,Lindsey W. Plasschaert,Shivani Aryal,Nicole A. Renaud,Zinger Yang,Rayman Choo-Wing,Angelica D. Pessotti,Nathaniel D. Kirkpatrick,Nadire Cochran,Walter Carbone,Rob Maher,Alicia Lindeman,Carsten Russ,John S. Reece-Hoyes,Gregory McAllister,Gregory R. Hoffman,Guglielmo Roma,Aron B. Jaffe +17 more
TL;DR: This work has identified TRRAP, an essential component of multiple histone acetyltransferase complexes, as a central regulator of MCC formation and regulates the expression of a network of genes involved in MCC differentiation and function, including several genes associated with human ciliopathies.
Bile acid analogues are activators of pyrin inflammasome.
Irina Alimov,Suchithra Menon,Nadire Cochran,Rob Maher,Qiong Wang,John Alford,John Concannon,Zinger Yang,Edmund Harrington,Luis Llamas,Alicia Lindeman,Gregory R. Hoffman,Tim Schuhmann,Carsten Russ,John S. Reece-Hoyes,Stephen M. Canham,Xinming Cai +16 more
TL;DR: It is surmised that pyrin inflammasome activation through microbiota-modified bile acid metabolites such as BAA473 and BAA485 plays a role in gut microbiota regulated intestinal immune response, and the discovery of these two bioactive compounds may help to further unveil the importance of pyrIn in gut homeostasis and autoimmune diseases.