Rita Morigi
University of Bologna
82 Papers
628 Citations
Rita Morigi is an academic researcher from University of Bologna. The author has contributed to research in topics: Thiazole & Chemistry. The author has an hindex of 26, co-authored 78 publications. Previous affiliations of Rita Morigi include Malaghan Institute of Medical Research & Molecular and Behavioral Neuroscience Institute.
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Papers
DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells
Alessio De Magis,Stefano G. Manzo,Marco Russo,Jessica Marinello,Rita Morigi,Olivier Sordet,Giovanni Capranico +6 more
TL;DR: It is established that specific G4 ligands stabilize G4s and simultaneously increase R-loop levels within minutes in human cancer cells, establishing a mechanistic model of G 4 ligand activity in cancer cells that can open new lines of investigation aiming at developing clinically effective G4ligands.
292
Synthesis and antitubercular activity of imidazo[2,1-b]thiazoles
Aldo Andreani,Massimiliano Granaiola,Alberto Leoni,Alessandra Locatelli,Rita Morigi,Mirella Rambaldi +5 more
TL;DR: A number of selected imidazo[2,1-b]thiazoles entered the screening at the Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF) and one of these compounds, 2-chloro-6-phenylimidazole, showed antitubercular activity, which planned the synthesis of new analogues bearing a substituted ring at the 6 position.
150
New isatin derivatives with antioxidant activity.
Aldo Andreani,Silvia Burnelli,Massimiliano Granaiola,Alberto Leoni,Alessandra Locatelli,Rita Morigi,Mirella Rambaldi,Lucilla Varoli,Mauro Andrea Cremonini,Giuseppe Placucci,Rinaldo Cervellati,Emanuela Greco +11 more
TL;DR: Three published antitumor agents showed a good chemical antioxidant activity and the main product was identified as 3,3-bis(4-amino-2,5-dimethoxyphenyl)-1-3-dihydroindol-2-one.
116
Potential antitumor agents. part 291: synthesis and potential coanthracyclinic activity of Imidazo[2,1-b]thiazole guanylhydrazones
Aldo Andreani,Alberto Leoni,Alessandra Locatelli,Rita Morigi,Mirella Rambaldi,Maurizio Recanatini,Vida Garaliene +6 more
TL;DR: The synthesis of new imidazo[2,1-b]thiazole guanylhydrazones which were tested as potential antitumor agents and three of these derivatives were the most potent and one of these showed a mild effect as CDK1 inhibitor.
79
Potential antitumor agents. 37. Synthesis and antitumor activity of guanylhydrazones from imidazo[2,1-b]thiazoles and from the new heterocyclic system thiazolo[2',3':2,3]imidazo[4,5-c]quinoline
Aldo Andreani,Massimiliano Granaiola,Alberto Leoni,Alessandra Locatelli,Rita Morigi,Mirella Rambaldi,Giorgio Lenaz,Romana Fato,Christian Bergamini,Giovanna Farruggia +9 more
TL;DR: The effect of the guanylhydrazone of 2-chloro-6-(2,5-dimethoxy-4-nitrophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde was investigated, and it was found to be an inhibitor of Complex III of the mitochondrial respiratory chain and is able to induce apoptosis in the cell lines HT29 and HL60.
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