Rinaldo Marini Bettolo
Sapienza University of Rome
40 Papers
325 Citations
Rinaldo Marini Bettolo is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Total synthesis & Aldol condensation. The author has an hindex of 12, co-authored 40 publications.
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Papers
Design, Synthesis and Applications of Hyaluronic Acid-Paclitaxel Bioconjugates†
TL;DR: Coupling a bioactive compound to a biocompatible polymer offers, in general, many advantages such as better drug solubilization, better stabilization, specific localization and controlled release.
Patent
Taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives
Luca Gilda De,Rinaldo Marini Bettolo,Luisa Maria Migneco +2 more
- 10 Oct 2003
TL;DR: In this paper, a method for the preparation of pharmaceutical compositions to be used in the field of oncology, in the treatment of autoimmune disorders and of restenosis, was proposed.
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A Total Synthesis of Aphidicolin: Stereospecific Synthesis of (±)‐3α, 18‐Dihydoxy‐17‐Noraphidicolan‐16‐one
TL;DR: In this paper, a simple, efficient, and stereospecific total synthesis of (±)-3α, 18-dihydroxy-17-noraphidicolan-16-one (2), by solvolytic rearrangement of the endo-bicyclo-[2.2] oct-5-en-2-yl methanesulfonate 16, is described.
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A new and simply available class of hydrosoluble bioconjugates by coupling paclitaxel to hyaluronic acid through a 4-hydroxybutanoic acid derived linker
Francesca Leonelli,Angela La Bella,Andrea Francescangeli,Roberta Joudioux,Agostina Lina Capodilupo,Marina Quagliariello,Luisa Maria Migneco,Rinaldo Marini Bettolo,Vittorio Crescenzi,Gilda De Luca,Davide Renier +10 more
TL;DR: A simple preparation of a new hydrosoluble pac litaxel bioconjugate 8, representing a new class of paclitaxel derivatives, is described.
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On the diastereoselectivity of the aqueous-acid-catalyzed intramolecular aldol condensation of 3-oxocyclohexaneacetaldehydes
Barbara De Santis,Anna Laura Iamiceli,Rinaldo Marini Bettolo,Luisa Maria Migneco,Rita Scarpelli,Giorgio Cerichelli,Giancarlo Fabrizi,Doriano Lamba +7 more
TL;DR: In this article, the factors responsible for the diastereoselective formation of 6-endo-hydroxybicyclo[2.2]octan-2-one by acid-catalyzed intramolecular aldol reaction of 3-oxocyclohexaneacetaldehydes have been investigated.
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