Rina Saksena
National Institutes of Health
36 Papers
556 Citations
Rina Saksena is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Tetrasaccharide & Bacillus anthracis. The author has an hindex of 20, co-authored 36 publications.
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Papers
Preparation of glycoconjugates by dialkyl squarate chemistry revisited.
TL;DR: D dimethyl squarate seemed to be the most convenient reagent for conversion of carbohydrate derivatives to species amenable for conjugation because it is a crystalline, easy to handle, and commercially available material with very good reactivity.
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Synthesis of the β anomer of the spacer-equipped tetrasaccharide side chain of the major glycoprotein of the Bacillus anthracis exosporium ☆
TL;DR: To synthesize the beta-anthrosyl linkage with high stereoselectivity, a linker-equipped rhamnotriose derivative was glycosylated with ethyl 4-azido-3-O-benzyl-2- O-bromoacetyl-4,6-dideoxy-1-thio-beta-d-glucopyranoside and gave the target substance.
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Chemoenzymatic synthesis of immunogenic meningococcal group C polysialic acid-tetanus Hc fragment glycoconjugates
Pumtiwitt C. McCarthy,Rina Saksena,Dwight C. Peterson,Che-Hung Lee,Yanming An,John F. Cipollo,Willie F. Vann +6 more
TL;DR: Sera of mice immunized with oligosialic acid-TetHc glycoconjugates contained much greater levels of polysaccharide-reactive IgG than the sera of control mice receiving unconjugated oligosianic acids, suggesting that chemoenzymatic synthesis may provide a viable method for making defined meningococcal vaccine candidates.
Synthetic fragments of Vibrio cholerae O1 Inaba O-specific polysaccharide bound to a protein carrier are immunogenic in mice but do not induce protective antibodies
Michael D. Meeks,Rina Saksena,Xingquan Ma,Terri K. Wade,Ronald K. Taylor,Pavol Kováč,William F. Wade +6 more
TL;DR: It is hypothesized that the anti-Inaba antibodies induced by the Inaba CHO-BSA conjugates have enough affinity to be screened via enzyme-linked immunosorbent assay but not enough to be protective in vivo.
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Synthesis of the tetrasaccharide side chain of the major glycoprotein of the Bacillus anthracis exosporium.
TL;DR: The correct structure of the natural product has been proven by chemical synthesis and the NMR characteristics of the compound are virtually identical with those of the alpha-anomer of the tetrasaccharide isolated from the major glycoprotein of the Bacillus anthracis exosporium.
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