Riko Nishimura
Osaka University
97 Papers
313 Citations
Riko Nishimura is an academic researcher from Osaka University. The author has contributed to research in topics: RUNX2 & Osteoblast. The author has an hindex of 41, co-authored 88 publications.
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Papers
BMP2 Regulates Osterix through Msx2 and Runx2 during Osteoblast Differentiation
Takuma Matsubara,Kumiko Kida,Akira Yamaguchi,Kenji Hata,Fumitaka Ichida,Hiroko Meguro,Hiroyuki Aburatani,Riko Nishimura,Toshiyuki Yoneda +8 more
TL;DR: Osterix is regulated via both Runx2-dependent and -independent mechanisms, and that Osterix controls osteoblast differentiation, at least in part, by regulating the expression of genes not controlled by Runx 2.
537
Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation.
Tomohiko Murakami,Atsushi Saito,Shin-ichiro Hino,Shinichi Kondo,Soshi Kanemoto,Kazuyasu Chihara,Hiroshi Sekiya,Kenji Tsumagari,Kimiko Ochiai,Kazuya Yoshinaga,Masahiro Saitoh,Riko Nishimura,Toshiyuki Yoneda,Ikuyo Kou,Tatsuya Furuichi,Shiro Ikegawa,Masahito Ikawa,Masaru Okabe,Akio Wanaka,Kazunori Imaizumi +19 more
TL;DR: The studies show that OASIS is critical for bone formation through the transcription of Col1a1 and the secretion of bone matrix proteins, and they reveal a new mechanism by which ER stress-induced signalling mediates bone formation.
397
Requirement of BMP-2-induced Phosphatidylinositol 3-Kinase and Akt Serine/Threonine Kinase in Osteoblast Differentiation and Smad-dependent BMP-2 Gene Transcription
Nandini Ghosh-Choudhury,Sherry L. Abboud,Riko Nishimura,Anthony J. Celeste,Lenin Mahimainathan,Goutam Ghosh Choudhury,Goutam Ghosh Choudhury +6 more
TL;DR: Together these data provide the first evidence that activation of BMP receptor serine/threonine kinase stimulates the PI 3 kinase/Akt pathway and define a role for this signal transduction pathway in BMP-specific Smad function during osteoblast differentiation.
316
Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo
Kazuya Masuda,Barry Ripley,Riko Nishimura,Takashi Mino,Osamu Takeuchi,Go Shioi,Hiroshi Kiyonari,Tadamitsu Kishimoto +7 more
TL;DR: AT-rich interactive domain-containing protein 5A (Arid5a) is identified as a unique RNA binding protein, which stabilizes IL-6 but not TNF-α mRNA through binding to the 3′ untranslated region of IL- 6 mRNA.
218
Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation.
Shuji Muramatsu,Makoto Wakabayashi,Takeshi Ohno,Katsuhiko Amano,Rika Ooishi,Toshinori Sugahara,Satoshi Shiojiri,Kosuke Tashiro,Yutaka Suzuki,Riko Nishimura,Satoru Kuhara,Sumio Sugano,Toshiyuki Yoneda,Akio Matsuda +13 more
TL;DR: The results suggest that TRPV4 regulates the SOX9 pathway and contributes to the process of chondrogenesis.
217