Rikard Holmdahl
Karolinska Institutet
674 Papers
7.3K Citations
Rikard Holmdahl is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Arthritis & T cell. The author has an hindex of 91, co-authored 644 publications. Previous affiliations of Rikard Holmdahl include Umeå University & University of Erlangen-Nuremberg.
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Papers
Hydroxyethylene isosteres introduced in type II collagen fragments substantially alter the structure and dynamics of class II MHC A(q)/glycopeptide complexes
Cecilia M. Lindgren,Ida Andersson,Ida Andersson,Lotta Berg,Doreen Dobritzsch,Changrong Ge,Sabrina Haag,Urszula Uciechowska,Rikard Holmdahl,Jan Kihlberg,Anna Linusson +10 more
TL;DR: Biological evaluation showed that A(q) binding and T cell recognition were dramatically reduced for the modified glycopeptides, although static models predicted similar binding modes as the native type II collagen fragment.
Type-II Collagen in the Pathogenesis of Rheumatoid Arthritis
Rikard Holmdahl
- 01 Jan 1992
TL;DR: In this chapter the descriptive findings of autoimmune reactions to cartilage-specific type-II collagen (CII) in RA are reviewed and the general requirements for recognition of these molecules by the immune system are discussed.
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Functional and signaling characterization of the neutrophil FPR2 selective agonist Act-389949
TL;DR: The data show that Act-389949 serves as an excellent tool-compound for further dissection of FPR2-regulated activities in vitro and in vivo and may therefore be used to develop the next generation of F PR signaling regulating anti-inflammatory therapeutics.
V beta 11+ T-lymphocyte expansion by toxic shock syndrome toxin-1 differs in mice bearing H-2q versus H-2b haplotypes.
TL;DR: The findings suggest that the T‐ cell repertoire, skewed by clonal deletion and inactivation of self‐reactive T cells, accounts for the different magnitude of Vβ11+ T‐cell expansion among the different mouse strains.
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NCF4 dependent intracellular reactive oxygen species regulate plasma cell formation
Chang He,Huqiao Luo,Ana Coelho,Meng Liu,Qijing Li,Jing Xu,Alexander Krämer,Stephen Malin,Zuyi Yuan,Rikard Holmdahl +9 more
TL;DR: In this article , the authors used mice harboring a mutation in the lipid endosomal membrane binding site (R58A) of NCF4 subunit to enhance the production of autoantibodies to collagen type II (COL2) and severe collagen-induced arthritis in mice.
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