Rikard Holmdahl
Karolinska Institutet
674 Papers
7.3K Citations
Rikard Holmdahl is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Arthritis & T cell. The author has an hindex of 91, co-authored 644 publications. Previous affiliations of Rikard Holmdahl include Umeå University & University of Erlangen-Nuremberg.
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Papers
Differential gene expression in pristane-induced arthritis susceptible DA versus resistant E3 rats
Lena Wester,Dirk Koczan,Jens Holmberg,Peter Olofsson,Hans-Jürgen Thiesen,Rikard Holmdahl,Saleh M. Ibrahim +6 more
TL;DR: Animal models are well suited for reproducible microarray analysis of candidate genes for arthritis, and all genes have functions that are potentially important for arthritis and nine of the genes are located within genomic regions previously associated with autoimmune disease.
Identification of the minimal glycopeptide core recognized by T cells in a model for rheumatoid arthritis
TL;DR: Synthesis and evaluation of CII260-267 carrying a beta-D-galactosyl moiety at position 264 revealed that this glycopeptide stimulated representative members from a panel of carbohydrate-specific T-cell hybridomas obtained in CIA.
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Type II Collagen in Cartilage Evokes Peptide-specific Tolerance and Skews the Immune Response
TL;DR: The data show that the immunodominance of CII recognition is directed towards heterologous determinants, and that T cells directed towards the corresponding autologous epitopes are tolerated without evidence of active suppression.
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Association of MHC and rheumatoid arthritis: Why is rheumatoid arthritis associated with the MHC genetic region? An introduction
TL;DR: It is under dispute whether other class II molecules are involved,such as DQ, or even other MHC molecules, such as tumor necrosis factor α, but let us say that the DR molecule (in particular, specific structures in its peptide binding pocket) does play an important role in the disease.
Cartilage oligomeric matrix protein specific antibodies are pathogenic
Hui Geng,Hui Geng,Kutty Selva Nandakumar,Anna Pramhed,Anders Aspberg,Anders Aspberg,Ragnar Mattsson,Rikard Holmdahl +7 more
TL;DR: The specificities of mAbs to COMP and their contribution to the development of arthritis are identified and will further improve the understanding of the autoantibody mediated immunopathologies occurring widely in rheumatoid arthritis (RA), as well as in other autoimmune disorders.