Rikard Holmdahl
Karolinska Institutet
674 Papers
7.3K Citations
Rikard Holmdahl is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Arthritis & T cell. The author has an hindex of 91, co-authored 644 publications. Previous affiliations of Rikard Holmdahl include Umeå University & University of Erlangen-Nuremberg.
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Papers
Association between protein tyrosine phosphatase 22 variant R620W in conjunction with the HLA-DRB1 shared epitope and humoral autoimmunity to an immunodominant epitope of cartilage-specific type II collagen in early rheumatoid arthritis.
Harald Burkhardt,Ulrike Hüffmeier,Bernd M. Spriewald,Beate Böhm,Rolf Rau,Stefan Kallert,Åke Engström,Rikard Holmdahl,André Reis +8 more
TL;DR: Allelic variants encoding the binding pocket for peptide presentation to T cells and a functional domain of a negative regulator of T cell receptor signaling (PTPN22*620W) synergize in early RA to break self tolerance toward C1(III), an evolutionarily conserved cartilage determinant that is also frequently targeted in arthritogenic humoral autoimmunity in mice.
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A recombinant vaccine effectively induces c5a-specific neutralizing antibodies and prevents arthritis.
Kutty Selva Nandakumar,Kutty Selva Nandakumar,Åsa Jansson,Bingze Xu,Niclas Rydell,Anna M. Blom,Rikard Holmdahl,Rikard Holmdahl +7 more
TL;DR: Exploitation of host immune response to generate sustained C5a neutralizing antibodies without significantly compromising C5/C5b activity is a useful strategy for developing an effective vaccine for antibody mediated and C 5a dependent inflammatory diseases.
Oestrogen is a Potent Immunomodulator of Murine Experimental Rheumatoid Disease
TL;DR: It is shown that oestrogen treatment suppresses development of type II collagen induced arthritis in mice and rats, which is a T-cell dependent experimental model for human RA and suggested that autoimmune diseases should be divided into two groups, one in which Oestrogen accelerates disease progression and another in which oestrogens is beneficial.
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Autoimmune Recognition of Cartilage Collagens
TL;DR: It is proposed that collagen-induced arthritis (CIA) is valuable for understanding the autoimmune recognition of cartilage collagen which precedes the outbreak of arthritis and may perpetuate its chronicity, and serves as an animal model of rheumatoid arthritis.
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Complex genetic control in a rat model for rheumatoid arthritis.
TL;DR: Suggestible evidence for an interaction where an effect of Pia7 and Pia1 on disease severity depends on DA homozygosity at specific loci, which themselves do not confer susceptibility is found.
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