Rien van Haperen
Erasmus University Rotterdam
64 Papers
899 Citations
Rien van Haperen is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Phospholipid transfer protein & Enos. The author has an hindex of 31, co-authored 56 publications. Previous affiliations of Rien van Haperen include Erasmus University Medical Center.
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Papers
Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress
Caroline Cheng,Dennie Tempel,Rien van Haperen,Arjen van der Baan,Frank Grosveld,Mat J.A.P. Daemen,Rob Krams,Rini de Crom +7 more
TL;DR: A perivascular shear stress modifier is developed that induces regions of lowered, increased, and lowered/oscillatory (ie, with vortices) shear stresses in mouse carotid arteries and studied plaque formation and composition, finding lowered shear stressed lesions induce larger lesions with a vulnerable plaque phenotype.
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A human monoclonal antibody blocking SARS-CoV-2 infection
Chunyan Wang,Wentao Li,Dubravka Drabek,Nisreen M.A. Okba,Rien van Haperen,Albert D.M.E. Osterhaus,Frank J. M. van Kuppeveld,Bart L. Haagmans,Frank Grosveld,Berend Jan Bosch +9 more
TL;DR: This cross-neutralizing antibody targets a communal epitope on these viruses and offers potential for prevention and treatment of COVID-19.
A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies.
Chunyan Wang,Rien van Haperen,Javier Gutiérrez-Álvarez,Wentao Li,Nisreen M.A. Okba,Irina C. Albulescu,Ivy Widjaja,Brenda van Dieren,Raúl Fernandez-Delgado,Isabel Sola,Daniel L. Hurdiss,Olalekan Daramola,Frank Grosveld,Frank J. M. van Kuppeveld,Bart L. Haagmans,Luis Enjuanes,Dubravka Drabek,Berend Jan Bosch +17 more
TL;DR: In this article, two human monoclonal antibodies were isolated from immunized humanized mice that display a remarkable cross-reactivity against distinct spike proteins of betacoronaviruses including SARS-CoV, SARS CoV-2, MERS CoV and the endemic human coronavirus HCoV-OC43.
Increased risk of atherosclerosis by elevated plasma levels of phospholipid transfer protein
Rien van Haperen,Arie van Tol,Teus van Gent,L.M. Scheek,Pim Visser,Arthur W.M. van der Kamp,Frank Grosveld,Rini de Crom +7 more
TL;DR: PLTP increases susceptibility to atherosclerosis by lowering HDL concentrations, and therefore it is suggested that an increase in PLTP is a novel, long term risk factor for atheros sclerosis in humans.
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Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein
Ivy Widjaja,Chunyan Wang,Rien van Haperen,Javier Gutiérrez-Álvarez,Brenda van Dieren,Nisreen M.A. Okba,V. Stalin Raj,Wentao Li,Raúl Fernandez-Delgado,Frank Grosveld,Frank J. M. van Kuppeveld,Bart L. Haagmans,Luis Enjuanes,Dubravka Drabek,Berend Jan Bosch +14 more
TL;DR: A set of human monoclonal antibodies that target functionally distinct domains of the MERS-CoV spike protein, which offer new ways to gain humoral protection in humans against the emerging MSPV by targeting different spike protein epitopes and functions.