Rie Wada
Keio University
5 Papers
1 Citations
Rie Wada is an academic researcher from Keio University. The author has contributed to research in topics: Reprogramming & GATA4. The author has an hindex of 4, co-authored 5 publications.
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Papers
Induction of human cardiomyocyte-like cells from fibroblasts by defined factors
Rie Wada,Naoto Muraoka,Kohei Inagawa,Hiroyuki Yamakawa,Kazutaka Miyamoto,Taketaro Sadahiro,Tomohiko Umei,Ruri Kaneda,Tomoyuki Suzuki,Tomoyuki Suzuki,Kaichiro Kamiya,Shugo Tohyama,Shinsuke Yuasa,Kiyokazu Kokaji,Ryo Aeba,Ryohei Yozu,Hiroyuki Yamagishi,Toshio Kitamura,Keiichi Fukuda,Masaki Ieda +19 more
TL;DR: It is demonstrated that human fibroblasts can be directly converted to iCMs by defined factors, which may facilitate future applications in regenerative medicine.
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Induction of Cardiomyocyte-Like Cells in Infarct Hearts by Gene Transfer of Gata4, Mef2c, and Tbx5
Kohei Inagawa,Kazutaka Miyamoto,Hiroyuki Yamakawa,Naoto Muraoka,Taketaro Sadahiro,Tomohiko Umei,Rie Wada,Yoshinori Katsumata,Ruri Kaneda,Koji Nakade,Chitose Kurihara,Yuichi Obata,Koichi Miyake,Keiichi Fukuda,Masaki Ieda +14 more
TL;DR: In vitro transduction of GMT retrovirus converted cardiac fibroblasts from the infarct region into cardiomyocyte-like cells with cardiac-specific gene expression and sarcomeric structures, and quantitative RT-PCR demonstrated that FACS-sorted 3F2A-transduced cells expressed cardiac- specific genes.
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•Journal Article
Abstract 15383: Direct Conversion of Cardiac Fibroblasts into Cardiomyocyte-Like Cells in vivo
Kohei Inagawa,Naoto Muraoka,Rie Wada,Hiroyuki Yamakawa,Kazutaka Miyamoto,Tomohiko Umei,Keiichi Fukuda,Masaki Ieda +7 more
TL;DR: Results indicate that endogenous cardiac fibroblasts can be a cell source for new cardiomyocytes and that direct cardiac reprogramming can be induced in vivo by local delivery of GMT into the infarct heart.
1
MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures
Naoto Muraoka,Hiroyuki Yamakawa,Kazutaka Miyamoto,Taketaro Sadahiro,Tomohiko Umei,Mari Isomi,Hanae Nakashima,Mizuha Akiyama,Rie Wada,Kohei Inagawa,Takahiko Nishiyama,Ruri Kaneda,Toru Fukuda,Shu Takeda,Shugo Tohyama,Hisayuki Hashimoto,Yoshifumi Kawamura,Naoki Goshima,Ryo Aeba,Hiroyuki Yamagishi,Keiichi Fukuda,Masaki Ieda +21 more
TL;DR: It is demonstrated that addition of miR‐ 133a (miR‐133) to Gata4, Mef2c, and Tbx5 (GMT) or GMT plus Mesp1 and Myocd improved cardiac reprogramming from mouse or human fibroblasts by directly repressing Snai1, a master regulator of epithelial‐to‐mesenchymal transition.