Rie Akiyama
Hiroshima University
9 Papers
87 Citations
Rie Akiyama is an academic researcher from Hiroshima University. The author has contributed to research in topics: Hepatitis B virus & HBsAg. The author has an hindex of 7, co-authored 7 publications. Previous affiliations of Rie Akiyama include Life Sciences Institute.
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Papers
HBx protein is indispensable for development of viraemia in human hepatocyte chimeric mice
Masataka Tsuge,Nobuhiko Hiraga,Rie Akiyama,Sachi Tanaka,Miyuki Matsushita,Fukiko Mitsui,Hiromi Abe,Shosuke Kitamura,Tsuyoshi Hatakeyama,Takashi Kimura,Daiki Miki,Nami Mori,Michio Imamura,Shoichi Takahashi,C. Nelson Hayes,Kazuaki Chayama +15 more
TL;DR: It was concluded that the HBx protein is indispensable for HBV replication and could be a target for antiviral therapy.
100
Circulating microRNA-22 correlates with microRNA-122 and represents viral replication and liver injury in patients with chronic hepatitis B.
Keiko Arataki,C. Nelson Hayes,C. Nelson Hayes,Sakura Akamatsu,Sakura Akamatsu,Rie Akiyama,Rie Akiyama,Hiromi Abe,Masataka Tsuge,Daiki Miki,Daiki Miki,Hidenori Ochi,Hidenori Ochi,Nobuhiko Hiraga,Nobuhiko Hiraga,Michio Imamura,Michio Imamura,Shoichi Takahashi,Hiroshi Aikata,Hiroshi Aikata,Tomokazu Kawaoka,Tomokazu Kawaoka,Hiroiku Kawakami,Hiroiku Kawakami,Waka Ohishi,Waka Ohishi,Kazuaki Chayama +26 more
TL;DR: Serum microRNA levels are significantly associated with multiple aspects of HBV infection and the biological meaning of the correlation between microRNA‐122 and HBsAg and should be investigated further.
G to A hypermutation of TT virus.
Masataka Tsuge,Chiemi Noguchi,Rie Akiyama,Miyuki Matsushita,Kana Kunihiro,Sachi Tanaka,Hiromi Abe,Fukiko Mitsui,Shosuke Kitamura,Tsuyoshi Hatakeyama,Takashi Kimura,Daiki Miki,Nobuhiko Hiraga,Michio Imamura,Shoichi Takahashi,C. Nelson Hayses,Kazuaki Chayama +16 more
TL;DR: The results show that hypermutated TTV exist in healthy individuals and HBV carriers and that TTV genomes were susceptible to immune reaction directed to HBV by interacting with APOBEC3 proteins.
31
Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A.
Sakura Akamatsu,Sakura Akamatsu,C. Nelson Hayes,C. Nelson Hayes,Hidenori Ochi,Hidenori Ochi,Takuro Uchida,Takuro Uchida,Hiromi Kan,Hiromi Kan,Eisuke Murakami,Eisuke Murakami,Hiromi Abe,Hiromi Abe,Masataka Tsuge,Daiki Miki,Daiki Miki,Rie Akiyama,Rie Akiyama,Nobuhiko Hiraga,Nobuhiko Hiraga,Michio Imamura,Michio Imamura,Hiroshi Aikata,Hiroshi Aikata,Tomokazu Kawaoka,Tomokazu Kawaoka,Yoshiiku Kawakami,Yoshiiku Kawakami,Kazuaki Chayama,Kazuaki Chayama +30 more
TL;DR: HCV infection is proposed to induce a more efficient antiviral response in individuals with the IFNL4 TT/TT genotype that results either in viral clearance or selection for viral adaptations.
26
Regulation of the Hepatitis B virus replication and gene expression by the multi-functional protein TARDBP.
Grace Naswa Makokha,Hiromi Abe-Chayama,Sajeda Chowdhury,C. Nelson Hayes,Masataka Tsuge,Tadahiko Yoshima,Yuji Ishida,Yizhou Zhang,Takuro Uchida,Chise Tateno,Rie Akiyama,Kazuaki Chayama +11 more
TL;DR: The protein’s broad interactome suggests that TARDBP may function as part of a RNA-binding scaffold involved in HBV replication and that the interaction between these proteins might be a target for development of anti-HBV drugs.