Rick W. Ransom
United States Military Academy
10 Papers
42 Citations
Rick W. Ransom is an academic researcher from United States Military Academy. The author has contributed to research in topics: Bradykinin receptor & Bradykinin. The author has an hindex of 8, co-authored 10 publications.
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Papers
Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor
TL;DR: Saturation binding analysis indicates that the human BK-2 receptor expressed in COS-7 cells binds BK with a KD of 0.13 nM, and Pharmacological characterization of the expressed BK receptor is consistent with the cDNA encoding a receptor of the Bk-2 subtype.
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Targeted Disruption of a B2 Bradykinin Receptor Gene in Mice Eliminates Bradykinin Action in Smooth Muscle and Neurons
Joseph A. Borkowski,Rick W. Ransom,Guy R. Seabrook,Myrna E. Trumbauer,Howard Y. Chen,Raymond G. Hill,Catherine D. Strader,J.F. Hess +7 more
TL;DR: In this article, the B2 bradykinin receptor gene was found to be homozygous for the targeted disruption of the gene encoding the BRB2 receptor, which results in a deletion of the entire coding sequence for the BRBP.
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In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α1A Receptor Antagonists for the Treatment of Benign Prostatic Hyperplasia
James C. Barrow,Philippe G. Nantermet,Harold G. Selnick,Kristen L. Glass,Kenneth E. Rittle,Kevin F. Gilbert,Thomas G. Steele,Carl F. Homnick,Roger M. Freidinger,Rick W. Ransom,Paul J. Kling,Duane R. Reiss,Theodore P. Broten,Terry W. Schorn,Raymond S.L. Chang,Stacey O'Malley,Timothy V. Olah,Joan D. Ellis,A. Barrish,Kelem Kassahun,Paula Leppert,Dhanapalan Nagarathnam,Carlos Forray +22 more
TL;DR: While many of the compounds tested displayed poor pharmacokinetics, compound 48 was found to be more potent than terazosin in both a rat model of prostate tone and a dog model of intra-urethral pressure without significantly affecting blood pressure.
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Binding modes of dihydroquinoxalinones in a homology model of bradykinin receptor 1.
Sookhee Ha,Pat J. Hey,Rick W. Ransom,C. Meacham Harrell,Kathryn L. Murphy,R. S. L. Chang,Tsing-Bau Chen,Dai-Shi Su,M. Kristine Markowitz,Mark G. Bock,Roger M. Freidinger,Fred Hess +11 more
TL;DR: The first homology model of human bradykinin receptor B1 generated from the crystal structure of bovine rhodopsin as a template was reported, using an automated docking procedure to gain insight into the molecular mechanism for receptor function and to optimize the dihydroquinoxalinone analogs.
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Identification of the critical residues of bradykinin receptor B1 for interaction with the kinins guided by site-directed mutagenesis and molecular modeling.
Sookhee Ha,Pat J. Hey,Rick W. Ransom,Mark G. Bock,Dai-Shi Su,Kathryn L. Murphy,R. S. L. Chang,Tsing-Bau Chen,Douglas J. Pettibone,J. Fred Hess +9 more
TL;DR: The data indicate that the B1 bradykinin binding pocket for agonists and antagonists is similar, but the manners in which they interact with the receptor do not completely overlap, and there is a potential to influence the receptor's ligand selectivity.
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