Rick Moore
Research Triangle Park
23 Papers
104 Citations
Rick Moore is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Nuclear receptor & Pregnane X receptor. The author has an hindex of 17, co-authored 22 publications. Previous affiliations of Rick Moore include National Institutes of Health.
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Papers
•Journal Article
Developmental exposure to diethylstilbestrol elicits demethylation of estrogen-responsive lactoferrin gene in mouse uterus
Shuanfang Li,Kimberly A. Washburn,Rick Moore,Tomohide Uno,Christina T. Teng,Retha R. Newbold,John A. McLachlan,Masahiko Negishi +7 more
TL;DR: In this paper, the effects of DES on DNA demethylation in five CpG sites (547, -533, -475, -464, and -454) immediately upstream from the estrogen response element of the lactoferrin promoter was determined in the uteri of immature (17-day-old) and mature (21-and 30-day old) mice treated neonatally with DES.
Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver.
TL;DR: The PXR-mediated repression of lipid metabolism in the fasting livers was investigated using Pxr–/– mice and results were consistent with the conclusion that PCN-activated P XR represses FoxA2-mediated transcription of Ctp1a and Hmgcs2 genes in fasting liver.
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Estrogen receptor α mediates 17α-ethynylestradiol-causing hepatotoxicity
Yukio Yamamoto,Rick Moore,Holly A. Hess,Grace L. Guo,Frank J. Gonzalez,Kenneth S. Korach,Robert R. Maronpot,Masahiko Negishi +7 more
TL;DR: In this paper, the effects of synthetic estrogen 17α-ethynylestradiol (EE2)-induced hepatotoxicity on bile acid and cholesterol transporters were investigated.
170
Dephosphorylation of Threonine 38 Is Required for Nuclear Translocation and Activation of Human Xenobiotic Receptor CAR (NR1I3)
Shingo Mutoh,Makoto Osabe,Kaoru Inoue,Rick Moore,Lee G. Pedersen,Lalith Perera,Yvette Rebolloso,Tatsuya Sueyoshi,Masahiko Negishi +8 more
TL;DR: CAR is defined as a cell signal-regulated constitutive active nuclear receptor that regulates nuclear translocation and activation of CAR and phosphorylation/dephosphorylation of the threonine is provided as the primary drug target for CAR activation.
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Characterization of Phenobarbital-inducible Mouse Cyp2b10 Gene Transcription in Primary Hepatocytes
TL;DR: The results indicate that sequences important for PB-induced transcription of Cyp2b10 gene are located in the distal promoter, which is responsible for the induced CAT activity.
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