Richard Van
University of Oklahoma
28 Papers
20 Citations
Richard Van is an academic researcher from University of Oklahoma. The author has contributed to research in topics: Chemistry & In vivo. The author has an hindex of 3, co-authored 13 publications.
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Papers
Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo.
Jing Yang,Wei Yin,Richard Van,Keyi Yin,Peng Wang,Chao Zheng,Biyue Zhu,Kathleen Ran,Can Zhang,Mohanraja Kumar,Yihan Shao,Chongzhao Ran +11 more
TL;DR: The authors develop turn-on chemiluminescent probes that bind amyloid beta plaques in vivo, and amplify the signal via chemILuminescence resonance energy transfer to the plaque-binding fluorescent molecule CRANAD-3.
Novel Reversible-Binding PET Ligands for Imaging Monoacylglycerol Lipase Based on the Piperazinyl Azetidine Scaffold.
Jian Rong,Wakana Mori,Xiaotian Xia,Michael A. Schafroth,Chunyu Zhao,Richard Van,Tomoteru Yamasaki,Jiahui Chen,Zhiwei Xiao,Ahmed Haider,Daisuke Ogasawara,Atsuto Hiraishi,Tuo Shao,Yiding Zhang,Zhen Chen,Fuwen Pang,Kuan Hu,Lin Xie,Masayuki Fujinaga,Katsushi Kumata,Yuancheng Gou,Yang Fang,Shuyin Gu,Huiyi Wei,Bao Liang,Hao Xu,Thomas Lee Collier,Yihan Shao,Richard E. Carson,Benjamin F. Cravatt,Lu Wang,Ming-Rong Zhang,Steven H. Liang +32 more
TL;DR: In this paper, a piperazinyl azetidine scaffold was used for the design and synthesis of multiple reversible monoacylglycerol lipase (MAGL) inhibitors.
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Accelerating Ab Initio Quantum Mechanical and Molecular Mechanical (QM/MM) Molecular Dynamics Simulations with Multiple Time Step Integration and a Recalibrated Semiempirical QM/MM Hamiltonian.
TL;DR: In this article , a modified protocol of the multiple time step (MTS) method for accelerating ai-QM/MM simulations of condensed-phase reactions is presented, which leads to an over 5-fold speedup over standard aiQM /MM simulations, without sacrificing the accuracy in the predicted free energy profile of the reaction.
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In vivo three-dimensional brain imaging with chemiluminescence probes in Alzheimer's disease models.
Jing Zhang,C.L. Wickizer,Weihua Ding,Richard Van,Liuyue Yang,Bi-yue Zhu,Jun Yang,Yanli Wang,Yongle Wang,Yulong Xu,Can Zhang,Shiqian Shen,Changning Wang,Yihan Shao,Chongzhao Ran +14 more
TL;DR: It is demonstrated that ADLumin-5 could be used for in vivo 3D brain imaging in transgenic mouse models of Alzheimer's disease and had a high quantum yield of chemiluminescence and could bind to amyloid beta (Aβ).
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Identification and Development of a New Positron Emission Tomography Ligand 4-(2-Fluoro-4-[11C]methoxyphenyl)-5-((1-methyl-1H-pyrazol-3-yl)methoxy)picolinamide for Imaging Metabotropic Glutamate Receptor Subtype 2 (mGlu2).
Tomoteru Yamasaki,Xiaofei Zhang,Katsushi Kumata,Yiding Zhang,Xiaoyun Deng,Masayuki Fujinaga,Zhen Chen,Wakana Mori,Kuan Hu,Hidekatsu Wakizaka,Akiko Hatori,Lin Xie,Masanao Ogawa,Nobuki Nengaki,Richard Van,Yihan Shao,Douglas J. Sheffler,Nicholas D. P. Cosford,Steven H. Liang,Ming-Rong Zhang +19 more
TL;DR: New candidates 5a-i that are potent negative allosteric modulators (NAMs) of mGlu2 are identified that exhibited high potency, high subtype selectivity, and favorable lipophilicity and PET study of [11C]5i indicated in vivo specific binding of m Glu2 in the rat brain.
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