Richard S. Houlston
Institute of Cancer Research
847 Papers
6.7K Citations
Richard S. Houlston is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Genome-wide association study & Cancer. The author has an hindex of 110, co-authored 768 publications. Previous affiliations of Richard S. Houlston include University of Southampton & Wellcome Trust Centre for Human Genetics.
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Papers
Risk of cancer death in first-degree relatives of patients with hereditary non-polyposis cancer syndrome (Lynch type II): a study of 130 kindreds in the United Kingdom.
TL;DR: A screening programme based on estimated risks could be offered to first‐degree relatives of index patients with Lynch type II cancer family syndrome.
Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk
Peter Broderick,Daniel Chubb,David W. Johnson,Niels Weinhold,Asta Försti,Amy Lloyd,Bianca Olver,Yussanne Ma,Sara E. Dobbins,Brian A Walker,Faith E. Davies,W Gregory,J. Anthony Child,Fiona M Ross,Graham Jackson,Kai Neben,Anna Jauch,Per Hoffmann,Thomas W. Mühleisen,Markus M. Nöthen,Markus M. Nöthen,Susanne Moebus,Ian Tomlinson,Hartmut Goldschmidt,Kari Hemminki,Kari Hemminki,Gareth J. Morgan,Richard S. Houlston +27 more
TL;DR: This study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights and observe a promising association at 3p22.1 and 7p15.3.
Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs
Yongchu Pan,Yongchu Pan,Hongliang Liu,Yanru Wang,Xiaozheng Kang,Zhensheng Liu,Kouros Owzar,Younghun Han,Li Su,Yongyue Wei,Rayjean J. Hung,Yonathan Brhane,John McLaughlin,Paul Brennan,Heike Bickeböller,Albert Rosenberger,Richard S. Houlston,Neil E. Caporaso,Maria Teresa Landi,Joachim Heinrich,Angela Risch,Xifeng Wu,Yuanqing Ye,David C. Christiani,Christopher I. Amos,Qingyi Wei +25 more
TL;DR: Two studies shed new light on the role of mRNA splicing genes in the development of lung cancer by using the summary data from six published genome-wide association studies to find 12 significant SNPs with false discovery rate (FDR) ≤0.05 mapped to one novel gene PRPF6.
Germline PTEN mutations in Cowden syndrome-like families.
Deborah J. Marsh,Patricia L. M. Dahia,Stacey Caron,Jennifer B. Kum,Ian M. Frayling,Ian Tomlinson,Kevin S. Hughes,Rosalind A. Eeles,Shirley Hodgson,V Murday,Richard S. Houlston,Charis Eng +11 more
TL;DR: It is concluded that germline PTEN mutations play a relatively minor role in CS-like families, and the strict International Cowden Consortium operational diagnostic criteria for CS are quite robust and should remain in place.
Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin’s lymphoma
Matthew Frampton,Miguel Inacio da Silva Filho,Peter Broderick,Hauke Thomsen,Asta Försti,Asta Försti,Jayaram Vijayakrishnan,Rosie Cooke,Victor Enciso-Mora,Per Hoffmann,Per Hoffmann,Markus M. Nöthen,Markus M. Nöthen,Amy Lloyd,Amy Holroyd,Lewin Eisele,Karl-Heinz Jöckel,Sabine Ponader,Elke Pogge von Strandmann,Tracy Lightfoot,Eve Roman,Annette Lake,Dorothy Montgomery,Ruth F. Jarrett,Anthony J. Swerdlow,Andreas Engert,Kari Hemminki,Richard S. Houlston +27 more
TL;DR: A GWAS meta-analysis with published GWASs identifies new HL susceptibility loci and maps intergenic to HBS1L and MYB, a region previously associated with hematopoiesis, and provides further insight into the genetic and biological basis of inherited susceptibility to HL.