Richard S. Houlston
Institute of Cancer Research
847 Papers
6.7K Citations
Richard S. Houlston is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Genome-wide association study & Cancer. The author has an hindex of 110, co-authored 768 publications. Previous affiliations of Richard S. Houlston include University of Southampton & Wellcome Trust Centre for Human Genetics.
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Papers
Germline polymorphisms and survival of lung adenocarcinoma patients: a genome-wide study in two European patient series.
Antonella Galvan,Francesca Colombo,Elisa Frullanti,Alice Dassano,Sara Noci,Yufei Wang,Timothy Eisen,Athena Matakidou,Luisa Tomasello,Marzia Vezzalini,Claudio Sorio,Matteo Dugo,Federico Ambrogi,Ilaria Iacobucci,Giovanni Martinelli,Matteo Incarbone,Marco Alloisio,Mario Nosotti,Davide Tosi,Luigi Santambrogio,Giuseppe Pelosi,Ugo Pastorino,Richard S. Houlston,Tommaso A. Dragani +23 more
TL;DR: These four germline variants represent promising candidates that, with further study, may help predict clinical outcome and the PTPRG locus may have a role in tumor progression.
Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer.
Chey Loveday,Kevin Litchfield,Max Levy,Amy Holroyd,Peter Broderick,Zsofia Kote-Jarai,Alison M. Dunning,Kenneth Muir,Julian Peto,Rosalind A. Eeles,Douglas F. Easton,Darshna Dudakia,Nick Orr,Nora Pashayan,Alison Reid,Robert Huddart,Richard S. Houlston,Clare Turnbull +17 more
TL;DR: TFCP2L1 joins the growing list of genes located within TGCT risk loci with biologically plausible roles in developmental transcriptional regulation, further highlighting the importance of this phenomenon in TGCT oncogenesis.
CYP1A1 polymorphisms and lung cancer risk: a meta-analysis.
TL;DR: The results from this analysis provide little support for the role of variation in the CYP1A1 gene defined by either polymorphisms represents as lung cancer risk factor.
Opportunities for precision oncology revealed by whole genome sequencing 10,478 cancers - the UK 100,000 Genomes Project
Ben Kinnersley,Amit Sud,Alex J. Cornish,Daniel Chubb,Richard Culliford,Andrew Everall,Aurélia Gruber,A. Larkeryd,Costas Mitsopoulos,Genomics England Research Consortium,David C. Wedge,Richard S. Houlston +11 more
TL;DR: In this article , the authors analyzed 10,478 patient tumour genomes spanning 35 cancer types recruited to the UK 100,000 Genomes Project and identified 330 driver genes, including 74 which are novel to any cancer.
Relationship between ARLTS1 polymorphisms and risk of chronic lymphocytic leukemia
TL;DR: This study does not support the postulate that variants of ARLTS1 influence the risk of chronic lymphocytic leukemia and there was no evidence for epistatic interaction between loci.