Richard Ramsden
University of Washington
12 Papers
36 Citations
Richard Ramsden is an academic researcher from University of Washington. The author has contributed to research in topics: Gene & Promoter. The author has an hindex of 9, co-authored 12 publications.
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Papers
Determining Protein Complex Structures Based on a Bayesian Model of in Vivo Förster Resonance Energy Transfer (FRET) Data
Massimiliano Bonomi,Massimiliano Bonomi,Riccardo Pellarin,Seung Joong Kim,Daniel Russel,Bryan A. Sundin,Michael Riffle,Daniel Jaschob,Richard Ramsden,Trisha N. Davis,Eric G D Muller,Andrej Sali +11 more
TL;DR: The Bayesian approach to determine macromolecular structures through a combination of in vivo FRETR data and data from other sources, such as electron microscopy and chemical cross-linking is implemented in the open-source Integrative Modeling Platform.
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Noninvasive Measurement of Protein Aggregation by Mutant Huntingtin Fragments or α-Synuclein in the Lens
Paul J. Muchowski,Richard Ramsden,QuangVu Nguyen,Ernest Arnett,Teri M.S. Greiling,Susan K. Anderson,John I. Clark +6 more
TL;DR: Transgenic mice in which aggregation-prone proteins that cause Huntington and Parkinson disease are expressed in the ocular lens are described and it is demonstrated that the endogenous chaperone activity of αB-crystallin suppresses aggregation in vivo.
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Dual NRF2 paralogs in Coho salmon and their antioxidant response element targets
TL;DR: These findings extend the conservation of Nrf2 and the ARE to salmonids, and should help inform future work in teleosts on mechanisms of redox control, as well as responsiveness of this pathway and its downstream antioxidant gene targets to chemical exposures in the environment.
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A large insertion in the Shiga-like toxin 2 gene (stx2) of an Escherichia coli O157:H7 clinical isolate
Karen C. Jinneman,Stephen D. Weagant,Janelle M. Johnson,Sharon L. Abbott,Walter E. Hill,Bradley J. Tenge,Ngoc Lan Dang,Richard Ramsden,Curtis J. Omiecinski +8 more
TL;DR: Six clinical Escherichia coli O157:H7 isolates were epidemiologically linked as part of an outbreak in which the most likely source was undercooked ground beef or cross-contamination from the ground beef to other food products at a Mexican-style restaurant.
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CRISPR-Generated Nrf2a Loss- and Gain-of-Function Mutants Facilitate Mechanistic Analysis of Chemical Oxidative Stress-Mediated Toxicity in Zebrafish.
Margaret G. Mills,Richard Ramsden,Eva Y. Ma,Jone Corrales,Lauren A. Kristofco,W. Baylor Steele,Gavin N. Saari,Fjodor Melnikov,Jakub Kostal,Terrance J. Kavanagh,Julie B. Zimmerman,Adelina Voutchkova-Kostal,Bryan W. Brooks,Philip Coish,Paul T. Anastas,Evan P. Gallagher +15 more
TL;DR: Several lines of zebrafish carrying different null or hyperactive mutations can be used to facilitate the identification of downstream gene targets of Nrf2a, better define the role of NRF2a in the toxicity of environmental chemicals, and further the study of diseases involving altered Nrf 2a function.
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