Richard Koche
Memorial Sloan Kettering Cancer Center
183 Papers
129 Citations
Richard Koche is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Biology & Chromatin. The author has an hindex of 36, co-authored 101 publications. Previous affiliations of Richard Koche include Broad Institute & Massachusetts Institute of Technology.
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Papers
Therapeutic remodeling of CBP transcription factor complex controls oncogenic gene expression in acute myeloid leukemia
Lauren Forbes,Paolo Cifani,Gerard Minuesa,Celine Chen,Sumiko Takao,Michael G. Kharas,Richard Koche,Alex Kentsis +7 more
TL;DR: This work shows that most subtypes of acute myeloid leukemia (AML) depend on the aberrant assembly of the MYB transcriptional co-activator complex, and proposes that convergently organized transcription factor complexes in AML cells control oncogenic gene expression programs.
MLL-AF9– and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C
Nan Zhu,Mo Chen,Rowena Eng,Joshua DeJong,Amit U. Sinha,Noushin F. Rahnamay,Richard Koche,Fatima Al-Shahrour,Janna Minehart,Chun-Wei Chen,Aniruddha J. Deshpande,Haiming Xu,S. Haihua Chu,Benjamin L. Ebert,Robert G. Roeder,Scott A. Armstrong +15 more
TL;DR: An in vivo shRNA screen and conditional mouse model results establish JMJD1C as an important mediator of MLL-AF9- and HOXA9-driven LSC function that is largely dispensable for HSC function.
Abstract 2648: ZFP36L2 orchestrates stress adaptive plasticity during injury repair and metastasis
Qingwen Jiang,Manisha Raghavan,Britney Forsyth,Aileen Rodriguez,Cyrus L. Tam,Sasha Balkaran,Saskia Hartner,Morgan Lallo,Ahmed Mahmoud,Andrew Moorman,Jura Pintar,Dana Pe'er,Richard Koche,Quaid Morris,Joseph Chan,Karuna Ganesh +15 more
Abstract 2552: TET2-mutant clonal hematopoiesis enrichment in the tumor microenvironment is an actionable driver of treatment resistance in solid tumors: Thyroid cancer as a paradigm
Pablo Sanchez Vela,Vera Tiedje,Julie L. Yang,Brian R. Untch,Laura Boucai,Aaron J Stonestrom,Alberto Bueno Costa,Sebastia Franch Exposito,Avi Srivastava,Marina Kerpelev,Jillian Greenberg,Matthew Wereski,Amanda Kulick,Kevin Chen,Tianyue Qin,Soo-Yeon Im,Anthony R. Martinez Benitez,Raquel Pluvinet,Merve Sahin,Kamal Menghrajani,Gnana P. Krishnamoorthy,Elisa de Stanchina,Ahmet Zehir,Rahul Satija,Jeffrey A. Knauf,Robert L. Bowman,M. Esteller,Sean M. Devlin,Michael F. Berger,Richard Koche,Ross L. Levine,James A. Fagin +31 more
Abstract SY34-02: Age-related and organ-specific host mosaicism as a driver of dormant cancer cell awakening
Julio A. Aguirre-Ghiso,Michael Papanicolaou,Pablo Sanchez Vela,Julie L Yang,Anton Safonov,Jacqueline Tao,Sebastia Franch Exposito,Vera Tiedje,Erica Dalla,Luis E. Valencia Salazar,Nicole Barth,Merve Sahin,Kevin Chen,Jinae Park,Matthew Wereski,Aishwarya Krishnan,Anthony R Martinez Benitez,Ryan Ptashkin,Mark E. Robson,Elisa de Stanchina,Lior Z. Braunstein,Ahmet Zehir,Elizabeth A. Comen,Larry Norton,Michael Berger,Richard Koche,Pedram Razavi,Ross Levine +27 more
TL;DR: This work may provide unprecedented insights into how a traceable age-related-mosaicism in the bone marrow (CH) may shape distant organs to be drive metastatic relapse.