Richard Koche
Memorial Sloan Kettering Cancer Center
183 Papers
129 Citations
Richard Koche is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Biology & Chromatin. The author has an hindex of 36, co-authored 101 publications. Previous affiliations of Richard Koche include Broad Institute & Massachusetts Institute of Technology.
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Papers
SUV39H1 disruption imparts functional persistence to CD28-costimulated human CAR T cells
Nayan Jain,Zeguo Zhao,Richard Koche,Yosi M. Gozlan,David Brocks,Tali Raveh-Sadka,D J Wells,Anton Dobrin,Yuzhe Shi,Michael Lopez,Gertrude Gunset,Michel Sadelain +11 more
TL;DR: In this article , the authors examined the effect of disrupting the histone methyl transferase, SUV39H1, on the functional persistence of human Rv-1928z CAR T cells.
EP16.03-030 AKT Inhibition as a Therapeutic Strategy to Constrain Histological Transdifferentiation in EGFR-mutant Lung Adenocarcinoma.
Álvaro Quintanal-Villalonga,Hiroya Taniguchi,Yingqian Zhan,Natasha Rekhtman,Brian Houck-Loomis,Richard Koche,H.A. Yu,Tanaya Sen,Charles M. Rudin +8 more
TL;DR: In lung adenocarcinomas (LUADs), lineage plasticity drives neuroendocrine and squamous cell transdifferentiation in the context of acquired resistance to targeted inhibition of driver mutations, with up to 14% and 9% incidences in EGFR-mutant tumors relapsed on EGFR inhibitors, respectively as discussed by the authors .
Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia
Sumiko Takao,Lauren Forbes,Masahiro Uni,Shuyuan Cheng,Jose Mario Bello Pineda,Yusuke Tarumoto,Yusuke Tarumoto,Paolo Cifani,Gerard Minuesa,Celine Chen,Michael G. Kharas,Robert K. Bradley,Christopher R. Vakoc,Richard Koche,Alex Kentsis +14 more
TL;DR: The authors showed that most subtypes of acute myeloid leukemia (AML) depend on the aberrant assembly of myb transcriptional co-activator complex, but not CREB or MLL1.
TET2 and TP53 Mutations Cooperatively Modulate the Response to Inflammation to Promote Leukemic Transformation
Pablo Sanchez Vela,Brianna Kelly,Claudia Brady,Jonathan Foox,J. Glass,Richard Koche,Matthew Wereski,Isabelle S. Csete,Sebastian El Ghaity-Beckley,Bridget K. Marcellino,R. L. Levine,Alan Shih +11 more
Erythroid and Megakaryocytic Differentiation Program in JAK2-Mutated Acute Myeloid Leukemia with or without Antecedent Myeloproliferative Neoplasm
Ying Liu,Shenon Sethi,Richard Koche,Qi Gao,Deepika Dilip,Jacob L. Glass,Pallavi Galera,Sonali Persaud,Tanmay Mishra,Xiaotian Sun,Dory Londono,Robert Cimera,Menglei Zhu,Christopher Famulare,Jee-Sun Baik,Himanshu Bhurtel,Maria E. Arcila,Ahmet Dogan,Ross Levine,Yanming Zhang,Mikhail Roshal,Raajit K. Rampal,Wenbin Xiao +22 more
TL;DR: In this paper , the protein, epigenomic and transcriptomic levels in JAK2-mutated acute myeloid leukemia (AML) patients were analyzed at protein, transcriptomic and protein expression levels.