Richard J. Lewis
University of Queensland
605 Papers
4.6K Citations
Richard J. Lewis is an academic researcher from University of Queensland. The author has contributed to research in topics: Chemistry & Conotoxin. The author has an hindex of 83, co-authored 545 publications. Previous affiliations of Richard J. Lewis include Fisons & University of Oxford.
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Papers
Structure of Caribbean Ciguatoxin Isolated from Caranx latus
TL;DR: In this article, the structure and configuration of C-CTX-1 (1), the major ciguatoxin isolated from the horse-eye jack (Caranx latus), has been determined from DQF-COSY, E-CoSY, TOCSY, NOESY, POESY and ge-HSQC experiments performed at 750 MHz and 500 MHz on a 0.13 pmol sample.
185
Modelling of compound combination effects and applications to efficacy and toxicity: state-of-the-art, challenges and perspectives
Krishna C. Bulusu,Rajarshi Guha,Daniel J. Mason,Richard J. Lewis,Eugene N. Muratov,Yasaman Kalantar Motamedi,Murat Cokol,Andreas Bender +7 more
TL;DR: The current state-of-the-art in the field of compound combination modelling is reviewed to support the development of approaches that, as it hope, will finally lead to an integration of chemical with systems-level biological information for predicting the effect of chemical mixtures.
184
Au–Pd separation enhances bimetallic catalysis of alcohol oxidation
Xiaoyang Huang,Ouardia Akdim,Mark Douthwaite,Kai Wang,Xiang Zhao,Richard J. Lewis,Samuel Pattisson,Isaac T Daniel,Peter J. Miedziak,Greg Shaw,David J. Morgan,Sultan Althahban,Thomas E. Davies,Qian He,Fei Wang,Jile Fu,Donald Bethell,Steven McIntosh,Christopher J. Kiely,Graham J. Hutchings +19 more
TL;DR: In this paper , the authors show that separating the gold and palladium components in bimetallic carbon-supported catalysts can almost double the reaction rate compared with that achieved with the corresponding alloy catalyst.
180
Structural and conformational determinants of macrocycle cell permeability
Björn Over,Pär Matsson,Pär Matsson,Christian Tyrchan,Per Artursson,Per Artursson,Bradley C. Doak,Michael Foley,Michael Foley,Constanze Hilgendorf,Stephen Johnston,Maurice D. Lee,Maurice D. Lee,Richard J. Lewis,Patrick McCarren,Giovanni Muncipinto,Giovanni Muncipinto,Ulf Norinder,Perry Matthew,Jeremy R Duvall,Jeremy R Duvall,Jan Kihlberg +21 more
TL;DR: Combined use of quantitative structure-permeability modeling and the procedure for conformational analysis now, for the first time, provides chemists with a rational approach to design cell- permeable non-peptidic macrocycles with potential for oral absorption.
179
Regulation of bacterial cell wall growth
TL;DR: Only now are the authors beginning to appreciate how these multiple levels of regulating PG synthesis enable the cell to propagate robustly with a defined cell shape under different and variable growth conditions.