Richard J. Lewis
University of Queensland
605 Papers
4.6K Citations
Richard J. Lewis is an academic researcher from University of Queensland. The author has contributed to research in topics: Chemistry & Conotoxin. The author has an hindex of 83, co-authored 545 publications. Previous affiliations of Richard J. Lewis include Fisons & University of Oxford.
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Papers
Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter
Andreas Brust,Ching-I Anderson Wang,Norelle L. Daly,Joe Kennerly,Mahsa Sadeghi,MacDonald J. Christie,Richard J. Lewis,Mehdi Mobli,Paul F. Alewood +8 more
TL;DR: The vicinal disulfide constrained cyclic peptidomimetics show high structural and functional similarity to the parent peptide, though with superior metabolic stability.
Spinal actions of ω-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model.
Angelo Jayamanne,Hyo-Jin Jeong,C I Schroeder,Richard J. Lewis,MacDonald J. Christie,Christopher W. Vaughan +5 more
TL;DR: Antagonists of the N‐type voltage gated calcium channel (VGCC), Cav2.2, have a potentially important role in the treatment of chronic neuropathic pain and ω‐conotoxins, such MVIIA and CVID are effective in neuropathicPain models.
Venom Peptides as a Rich Source of Cav2.2 Channel Blockers
TL;DR: Venomous animals are rich sources of remarkably potent and selective Cav2.2 inhibitors from venoms and their potential as drug leads, but side effects in humans currently limit their clinical use.
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