/pdf/covid-19-is-a-systemic-vascular-hemopathy-insight-for-3tpozo38xs.pdf

COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects.

Caplacizumab prevents refractoriness and mortality in acquired thrombotic thrombocytopenic purpura: integrated analysis.

Thrombotic microangiopathy (TMA) is characterized by thrombocytopenia, microangiopathic haemolytic anaemia and end organ damage. TMAs have varying underlying pathophysiology and can therefore present with an array of clinical presentations. Renal involvement is common as the kidney is particularly susceptible to the endothelial damage and microvascular occlusion. TMAs require rapid assessment, diagnosis, and commencement of appropriate treatment due to the high morbidity and mortality associated with them. Ground‐breaking research into the pathogenesis of TMAs over the past 20 years has driven the successful development of targeted therapeutics revolutionizing patient outcomes. This review outlines the clinical presentations, pathogenesis, diagnostic tests and treatments for TMAs.

https://eprints.ncl.ac.uk/file_store/production/284613/B57DF350-80B8-47EF-97A0-2B3863814B25.pdf

Diagnosis and treatment of thrombotic microangiopathy

http://www.cell.com/article/S1525001622000090/pdf

Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment

/pdf/real-world-effectiveness-of-caplacizumab-vs-the-standard-of-133esm3c.pdf

Real-world effectiveness of caplacizumab vs the standard of care in immune thrombotic thrombocytopenic purpura

Real-world experience with caplacizumab in the management of acute TTP

A young woman developed a line-associated deep vein thrombosis (DVT), which was treated with low molecular weight heparin (dalteparin). 8 days later, the DVT had significantly extended-in spite of therapeutic heparin levels. A diagnosis of heparin-induced thrombocytopenia and thrombosis (HITT) was considered, but the platelet count had not dropped. Nevertheless, a HITT assay was carried out which came back positive, with a repeat assay confirming the result. Dalteparin was stopped and apixaban treatment started, with symptomatic recovery over the following days and weeks.

/pdf/unusual-case-of-venous-thrombosis-3emlqgaco8.pdf

Unusual case of venous thrombosis

Warfarin is frequently prescribed as a long-term anticoagulant in patients with end-stage kidney disease as direct oral anticoagulants undergo renal excretion. Anticoagulation is a rare cause of alopecia in adults and is thought to be due to the promotion of the 'resting phase' of hair follicles. In this case report, a prevalent haemodialysis female patient required long-term anticoagulation following a complex pulmonary embolus and dialysis access complications. After commencing warfarin therapy, the patient reported generalised loss and thinning of her hair. All other potential causes were excluded. Cessation of warfarin therapy and conversion to apixaban with close monitoring alleviated the hair loss. Warfarin therapy is a rare cause of alopecia but should be considered in patients on long-term anticoagulation when other diagnoses have been excluded. Hair loss has a profoundly negative impact on patient quality of life and should prompt investigation to determine the underlying cause.

Resolution of warfarin-induced alopecia with conversion to apixaban.

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Real-world experience with caplacizumab in the management of acute TTP

Unusual case of venous thrombosis

Resolution of warfarin-induced alopecia with conversion to apixaban.