Richard C. Boucher
University of North Carolina at Chapel Hill
520 Papers
8.3K Citations
Richard C. Boucher is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Cystic fibrosis & Medicine. The author has an hindex of 129, co-authored 490 publications. Previous affiliations of Richard C. Boucher include American Heart Association & Durham University.
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Papers
SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.
Yixuan J. Hou,Kenichi Okuda,Caitlin E. Edwards,David R. Martinez,Takanori Asakura,Kenneth H. Dinnon,Takafumi Kato,Rhianna E. Lee,Boyd Yount,Teresa M. Mascenik,Gang Chen,Kenneth N. Olivier,Andrew J. Ghio,Longping V. Tse,Sarah R. Leist,Lisa E. Gralinski,Alexandra Schäfer,Hong Dang,Rodney C. Gilmore,Satoko Nakano,Ling Sun,M. Leslie Fulcher,Alessandra Livraghi-Butrico,Nathan I. Nicely,Mark J. Cameron,Cheryl M. Cameron,David J. Kelvin,David J. Kelvin,Aravinda M. de Silva,David M. Margolis,Alena J. Markmann,Luther A. Bartelt,Ross E. Zumwalt,Fernando J. Martinez,Steven P. Salvatore,Alain C. Borczuk,Purushothama Rao Tata,Vishwaraj Sontake,Adam J. Kimple,Ilona Jaspers,Wanda K. O'Neal,Scott H. Randell,Richard C. Boucher,Ralph S. Baric +43 more
TL;DR: The nasal susceptibility to SARS-CoV-2 with likely subsequent aspiration-mediated virus seeding to the lung in SARS/COVID-19 pathogenesis is highlighted and reagents provide a foundation for investigations into virus-host interactions in protective immunity, host susceptibility, and virus pathogenesis.
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Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients
D. Worlitzsch,Robert Tarran,Martina Ulrich,Ute E. Schwab,Aynur Cekici,Keith C. Meyer,Peter Birrer,Gabriel Bellon,Jürgen Berger,Tilo Weiss,Konrad Botzenhart,James R. Yankaskas,Scott H. Randell,Richard C. Boucher,Gerd Döring +14 more
TL;DR: In CF patients with established lung disease, Pseudomonas aeruginosa was located within hypoxic mucopurulent masses in airway lumens, and in vitro studies revealed that CF-specific increases in epithelial O(2) consumption, linked to increased airway surface liquid (ASL) volume absorption and mucus stasis, generated steep hypoxic gradients within thickened mucus on CF epithelial surfaces prior to infection.
Mucus clearance as a primary innate defense mechanism for mammalian airways
TL;DR: The role of mucus clearance in the lung is focused on as the more important innate defense mechanism in health and disease, including CF.
CFTR as a cAMP-dependent regulator of sodium channels.
M. J. Stutts,Cecilia M. Canessa,John C. Olsen,M Hamrick,Jonathan A. Cohn,Bernard C. Rossier,Richard C. Boucher +6 more
TL;DR: In CF airway epithelia, the absence of this second function of CFTR as a cAMP-dependent regulator likely accounts for abnormal sodium transport.
1.1K
Evidence for Periciliary Liquid Layer Depletion, Not Abnormal Ion Composition, in the Pathogenesis of Cystic Fibrosis Airways Disease
Hirotoshi Matsui,Barbara R. Grubb,Robert Tarran,Scott H. Randell,John T. Gatzy,C. William Davis,Richard C. Boucher +6 more
TL;DR: In this paper, two hypotheses, "hypotonic [low salt]/defensin" and "isotonic volume transport/mucus clearance", attempt to link defects in cystic fibrosis transmembrane conductance regulator-mediated ion transport to CF airways disease.
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