Richard B. Kim
University of Western Ontario
5 Papers
28 Citations
Richard B. Kim is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Trimethylamine N-oxide & Case-control study. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Richard B. Kim include London Health Sciences Centre.
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Papers
Trimethylamine- N -oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease
Aze Wilson,Wendy A. Teft,Bridget L. Morse,Yun-Hee Choi,Sarah Woolsey,Marianne K. DeGorter,Robert A. Hegele,Rommel G. Tirona,Richard B. Kim +8 more
TL;DR: Decreased TMAO levels are seen in IBD compared to a non-IBD population and may have potential as a biomarker to support IBD diagnosis as well as to assess disease activity in UC.
Identification and Characterization of Trimethylamine-N-oxide Uptake and Efflux Transporters.
Wendy A. Teft,Bridget L. Morse,Brenda F. Leake,Aze Wilson,Sara E. Mansell,Robert A. Hegele,Richard H. Ho,Richard B. Kim,Richard B. Kim +8 more
TL;DR: After screening a large array of uptake transporters, it is shown organic cation transporter 2 (OCT2) is the key transporter for TMAO cellular uptake, suggesting the importance of Oct2 in facilitating the uptake of T MAO into renal tubular cells in vivo.
Pharmacokinetic profiles for oral and subcutaneous methotrexate in patients with Crohn's disease
Aze Wilson,V. Patel,Nilesh Chande,Terry Ponich,Brad L. Urquhart,Linda J. Asher,Yun-Hee Choi,Rommel G. Tirona,Richard B. Kim,Jamie Gregor +9 more
TL;DR: Methotrexate (MTX) is administered subcutaneously to Crohn's Disease patients and there are very few studies evaluating the use of oral MTX in CD.
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HLA-DQA1-HLA-DRB1 polymorphism is a major predictor of azathioprine-induced pancreatitis in patients with inflammatory bowel disease.
Aze Wilson,L. E. Jansen,Rhiannon V. Rose,Jamie Gregor,Terry Ponich,Nilesh Chande,Reena Khanna,Brian Yan,Vipul Jairath,Nitin Khanna,Michael Sey,Melanie D. Beaton,K. McIntosh,Wendy A. Teft,Richard B. Kim +14 more
TL;DR: A genome wide association study (GWAS) identified a strong association between the Class II HLA gene region polymorphism (rs2647087) and thiopurine‐induced pancreatitis.
Trimethylamine-N-oxide: a link between the gut microbiome, bile acid metabolism, and atherosclerosis.
TL;DR: The interplay between TMAO and bile acid metabolism mediated through multiple factors, such as the gut microbiome, farnesoid X receptor signaling, and flavin monooxygenase 3 activity, may help identify another pathway by which atherosclerosis occurs.