Richard B. Herbert
University of Leeds
103 Papers
952 Citations
Richard B. Herbert is an academic researcher from University of Leeds. The author has contributed to research in topics: Phenazine & Bicyclomycin. The author has an hindex of 20, co-authored 103 publications.
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Papers
•Book
The Biosynthesis of Secondary Metabolites
Richard B. Herbert
- 10 Dec 1981
TL;DR: In this paper, the authors present a method for the synthesis of polyacetylenes and prostaglandins from the shikimic acid pathway, which can be classified into three categories: primary, secondary and tertiary.
226
Novel benzodiazepine receptor partial agonists: oxadiazolylimidazobenzodiazepines.
Frank Watjen,Raymond Baker,Mogens Engelstoff,Richard B. Herbert,Angus Murray Macleod,Anthony Knight,Kevin John Merchant,J. D. Moseley,John Saunders,Christopher John Swain,Erik H. F. Wong,James P. Springer +11 more
TL;DR: The synthesis and biochemical evaluation of a series of oxadiazole derivatives of imidazobenzodiazepines related to the benzodiazepine antagonist Ro 15-1788 (2a) are reported, and it is concluded that the antagonist behavior of 2a relies upon the hydrogen-bond-acceptor properties of the ester carbonyl oxygen whereas for the oxadrazole series this site is localized at theImidazole nitrogen.
138
Microbial Drug Efflux Proteins of the Major Facilitator Superfamily
Massoud Saidijam,Giulia Benedetti,Qinghu Ren,Zhiqiang Xu,Christopher J. Hoyle,S.L. Palmer,Alison Ward,Kim E. Bettaney,Gerda Szakonyi,Johan Meuller,Scott Morrison,Martin K Pos,Patrick Butaye,Karl Walravens,Kate P. Langton,Richard B. Herbert,Ronald A. Skurray,Ronald A. Skurray,Ian T. Paulsen,John O'Reilly,Nicholas G. Rutherford,Melissa H. Brown,Melissa H. Brown,Roslyn M. Bill,Peter J. F. Henderson +24 more
TL;DR: A structural genomics approach for the amplified expression, purification and characterisation of prokaryotic drug efflux proteins of the 'Major Facilitator Superfamily' of transport proteins from Helicobacter pylori, Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, Bacillus subtilis, Brucella melitensis, Campylobacter jejuni and Neisseria meningitides is described.
110
The nucleoside transport proteins, NupC and NupG, from Escherichia coli: specific structural motifs necessary for the binding of ligands
Simon G. Patching,Stephen A. Baldwin,Alexander D. Baldwin,James D. Young,Maurice P. Gallagher,Peter J. F. Henderson,Richard B. Herbert +6 more
TL;DR: The pattern of inhibition of NupC by differing nucleoside analogues confirmed the functional relationship of the bacterial transporter to members of the human concentrative nucleosid transporter (CNT) family and reaffirmed the use of theacterial protein as an experimental model for these physiologically and clinically important mammalian proteins.
80
Novel Benzodiazepine Receptor Partial Agonists: Oxadiazolylimidazobenzodiazepines.
Frank Watjen,Raymond Baker,Mogens Engelstoff,Richard B. Herbert,Angus Murray Macleod,Anthony Knight,Kevin John Merchant,J. D. Moseley,John Saunders,Christopher John Swain,Erik H. F. Wong,James P. Springer +11 more
TL;DR: In this article, the synthesis and biochemical evaluation of a series of oxadiazole derivatives of imidazobenzodiazepines related to the benzodiazepine antagonist Ro 15-1788 (2a) are reported.
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