Rian L. Griffiths
University of Birmingham
32 Papers
218 Citations
Rian L. Griffiths is an academic researcher from University of Birmingham. The author has contributed to research in topics: Mass spectrometry & Mass spectrometry imaging. The author has an hindex of 14, co-authored 25 publications. Previous affiliations of Rian L. Griffiths include University of Nottingham.
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Papers
Hyperspectral visualization of mass spectrometry imaging data.
Judith M. Fonville,Claire L Carter,Luis Pizarro,Luis Pizarro,Rory T. Steven,Andrew Palmer,Rian L. Griffiths,Patricia F. Lalor,John C. Lindon,Jeremy K. Nicholson,Elaine Holmes,Josephine Bunch +11 more
TL;DR: An intuitive color-coding scheme based on hyperspectral imaging methods is developed to generate a single overview image of this complex data set, based on spectral characteristics, such that pixels with similar molecular profiles are displayed with similar colors.
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LESA FAIMS Mass Spectrometry for the Spatial Profiling of Proteins from Tissue
Rian L. Griffiths,Andrew J. Creese,Alan M. Race,Josephine Bunch,Josephine Bunch,Helen J. Cooper +5 more
TL;DR: The results show that the number of different protein species detected can be significantly increased by incorporating FAIMS into the workflow and the spatial distributions of proteins identified were in good agreement indicating thatFAIMS is a suitable tool for inclusion in mass spectrometry imaging workflows.
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Liquid extraction surface analysis field asymmetric waveform ion mobility spectrometry mass spectrometry for the analysis of dried blood spots
TL;DR: It is shown that incorporation of FAIMS in the workflow enables gas-phase separation of lipid and protein molecular classes, enabling analysis of both haemoglobin and a range of lipids from a single extraction sample and has implications for multiplexed clinical assays of multiple analytes.
Native Liquid Extraction Surface Analysis Mass Spectrometry: Analysis of Noncovalent Protein Complexes Directly from Dried Substrates.
TL;DR: Native LESA mass spectrometry of noncovalent protein complexes of myoglobin and hemoglobin from a range of surfaces is demonstrated and the 'contact’ LESA approach was particularly suitable for the analysis of hemoglobin tetramers from DBS.
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Comprehensive LESA Mass Spectrometry Imaging of Intact Proteins by Integration of Cylindrical FAIMS
Rian L. Griffiths,Jim Hughes,Susan E. Abbatiello,Michael W. Belford,Iain B. Styles,Helen J. Cooper +5 more
TL;DR: A newly introduced cylindrical FAIMS device (theFAIMS Pro) coupled with a Thermo Fusion Lumos mass spectrometer for liquid extraction surface analysis mass spectromaetry imaging of intact proteins in thin tissue sections from rat testes, kidney, and brain is evaluated.