Rian Craig
San Diego State University
3 Papers
247 Citations
Rian Craig is an academic researcher from San Diego State University. The author has contributed to research in topics: NF-κB & p38 mitogen-activated protein kinases. The author has an hindex of 3, co-authored 3 publications.
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Papers
p38 MAPK and NF-κB Collaborate to Induce Interleukin-6 Gene Expression and Release EVIDENCE FOR A CYTOPROTECTIVE AUTOCRINE SIGNALING PATHWAY IN A CARDIAC MYOCYTE MODEL SYSTEM
Rian Craig,Andrea M Larkin,Amy M Mingo,Donna J. Thuerauf,Catherine Andrews,Patrick M. McDonough,Christopher C. Glembotski +6 more
TL;DR: By stimulating both p38 and NF-kappaB, Tak1-activating cytokines, like TNF-alpha, can induce IL-6 expression and release and the myocyte-derived IL- 6 may then function in an autocrine and/or paracrine fashion to augment myocardial cell survival during stresses that activate p38.
352
MKK6 Activates Myocardial Cell NF-κB and Inhibits Apoptosis in a p38 Mitogen-activated Protein Kinase-dependent Manner *
Dietmar Zechner,Rian Craig,Deanna S. Hanford,Patrick M. McDonough,Roger A. Sabbadini,Christopher C. Glembotski +5 more
TL;DR: The findings suggest that the overexpression of MKK6 (Glu) may foster growth and survival of cardiac myocytes by protecting them from apoptosis in a p38-dependent manner.
247
The Cytoprotective Effects of the Glycoprotein 130 Receptor-coupled Cytokine, Cardiotrophin-1, Require Activation of NF-κB
TL;DR: Results indicate that CT-1 signals through p38, ERK, and Akt in a parallel manner to activate NF-κB and that NF-σB is required for CT- 1 to mediate its full cytoprotective effects in cardiac myocytes.