Reyna Favis
Cornell University
17 Papers
115 Citations
Reyna Favis is an academic researcher from Cornell University. The author has contributed to research in topics: COLD-PCR & DNA microarray. The author has an hindex of 11, co-authored 17 publications. Previous affiliations of Reyna Favis include Janssen Pharmaceutica.
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Papers
Detecting Colorectal Cancer in Stool With the Use of Multiple Genetic Targets
Seung Myung Dong,Giovanni Traverso,Constance M. Johnson,Li Geng,Reyna Favis,Kevin A. Boynton,Kenji Hibi,Steven N. Goodman,Matthew D'Allessio,Philip B. Paty,Stanley R. Hamilton,David Sidransky,Francis Barany,Bernard Levin,Anthony P. Shuber,Kenneth W. Kinzler,Bert Vogelstein,Jin Jen,Jin Jen +18 more
TL;DR: Three genetic targets-TP53, BAT26, and K-RAS-were used to detect tumor-associated mutations in the stool prior to or without regard to the molecular analyses of the paired tumors, able to detect the majority of colorectal cancers by analyzing stool DNA for just three genetic markers.
383
Universal DNA array detection of small insertions and deletions in BRCA1 and BRCA2
Reyna Favis,Joseph P. Day,Norman P. Gerry,Catherine M. Phelan,Steven A. Narod,Francis Barany +5 more
TL;DR: The results demonstrate that universal microarray analysis of PCR/PCR/LDR products permits rapid identification of small insertion and deletion mutations in the context of both clinical diagnosis and population studies.
213
The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability
Michael Overholtzer,Michael Overholtzer,Pulivarthi H. Rao,Reyna Favis,Xin Yan Lu,Michael B. Elowitz,Francis Barany,Marc Ladanyi,Richard Gorlick,Arnold J. Levine +9 more
TL;DR: It is demonstrated that the inactivation of p53 in osteosarcomas directly by mutation versus indirectly by HDM2 amplification may have different cellular consequences with respect to the stability of the genome.
202
Classification of BRCA1 missense variants of unknown clinical significance
Catherine M. Phelan,V. Dapic,B. Tice,Reyna Favis,Elaine Kwan,Francis Barany,Siranoush Manoukian,Paolo Radice,R. B. van der Luijt,B. P. M. Van Nesselrooij,Georgia Chenevix-Trench,kConFab,Trinidad Caldés,M. De La Hoya,S. Lindquist,Sean V. Tavtigian,David E. Goldgar,Åke Borg,Steven A. Narod,Alvaro N.A. Monteiro +19 more
TL;DR: A combination of several methods provides a more powerful way of identifying variants that are causally linked to a high risk of breast and ovarian cancer.
105
An endonuclease/ligase based mutation scanning method especially suited for analysis of neoplastic tissue
Jianmin Huang,Brian W. Kirk,Reyna Favis,Thierry Soussi,Philip B. Paty,Weiguo Cao,Weiguo Cao,Francis Barany +7 more
TL;DR: EndoV/Ligase mutation scanning combined with PCR/LDR/Universal array proved superior to automated DNA sequencing for detecting p53 mutations in colon tumors and for analysing tumor DNA containing a minority of the unknown mutation.
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