21 Papers
109 Citations
Rex Sun is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Immune system & Nematode infection. The author has an hindex of 15, co-authored 21 publications.
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Papers
Th2 cytokine-Induced Alterations in Intestinal Smooth Muscle Function Depend on Alternatively Activated Macrophages
Aiping Zhao,Joseph F. Urban,Robert M. Anthony,Rex Sun,Jennifer A. Stiltz,Nico van Rooijen,Thomas A. Wynn,William C. Gause,Terez Shea-Donohue +8 more
TL;DR: Data show that the phenotype of macrophages is determined by the local immune environment and that alternatively activated macrophage markers play a major role in the effects of Th2 cytokines, IL-4 and IL-13, on intestinal smooth muscle function.
186
Macrophages as IL-25/IL-33-Responsive Cells Play an Important Role in the Induction of Type 2 Immunity
Zhonghan Yang,Zhonghan Yang,Viktoriya Grinchuk,Joseph F. Urban,Jennifer A. Bohl,Rex Sun,Luigi Notari,Shu Yan,Thirumalai R. Ramalingam,Achsah D. Keegan,Thomas A. Wynn,Terez Shea-Donohue,Aiping Zhao +12 more
TL;DR: It is demonstrated that macrophages as IL-25/IL-33-responsive cells play an important role in inducing type 2 immunity using both in vitro and in vivo approaches, and represent a unique population of the innate immune cells pivotal totype 2 immunity and a potential therapeutic target in controlling type 1 immunity-mediated inflammatory pathologies.
Parasitic Nematode-Induced Modulation of Body Weight and Associated Metabolic Dysfunction in Mouse Models of Obesity
Zhonghan Yang,Zhonghan Yang,Viktoriya Grinchuk,Allen Smith,Bolin Qin,Jennifer A. Bohl,Rex Sun,Luigi Notari,Zhongyan Zhang,Hiromi Sesaki,Joseph F. Urban,Terez Shea-Donohue,Aiping Zhao +12 more
TL;DR: The effects of nematode infection against obesity and the associated metabolic dysfunction in mice were investigated and resulted in a phenotypic change in adipose tissue macrophages that was characterized by upregulation of alternative activation markers.
110
Critical Role of IL-25 in Nematode Infection-Induced Alterations in Intestinal Function
Aiping Zhao,Joseph F. Urban,Rex Sun,Jennifer A. Stiltz,Motoko Morimoto,Luigi Notari,Kathleen B. Madden,Zhonghan Yang,Viktoriya Grinchuk,Thirumalai R. Ramalingam,Thomas A. Wynn,Terez Shea-Donohue +11 more
TL;DR: IL-25 plays a critical role in nematode infection-induced alterations in intestinal function that are important for host protective immunity, and IL-13 is the major downstream Th2 cytokine responsible for the IL-25 effects.
109
Mechanisms of smooth muscle responses to inflammation
TL;DR: This work has demonstrated the relevance of extracellular proteases, of endogenous or exogenous origin, redox imbalance, or epigenetic mechanisms, to gastrointestinal dismotility and inflammation in the context of functional and organic disorders.