Reuben J. Hoffmann
7 Papers
Reuben J. Hoffmann is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has co-authored 4 publications.
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Papers
A tumour-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer
Estela Gonzalez-Gualda,David Macías,Samir Morsli,Jose Ezequiel Martin,Hui-Ling Ou,M. Denholm,Ioana Olan,Reuben J. Hoffmann,Mark A. Dane,Dimitris Veroutis,Guillermo Medrano,Francisca Mulero,Carla P. Martins,Mariano Barbacid,Vassilis G. Gorgoulis,James E. Korkola,Doris Rassl,Gary J. Doherty,Robert C. Rintoul,Masashi Narita,Daniel Muñoz-Espín +20 more
TL;DR: It is shown that cisplatin-derived SASP enhances the malignant phenotype of lung cancer cells, and addition of TGFBR1 inhibitors to platinum-based chemotherapy reduces tumour burden and improves survival, providing pre-clinical proof-of-concept for future trial designs.
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Identification of senescence-associated drivers of tumour growth and progression using a novel microarray platform
Hui‐Ling Ou,Reuben J. Hoffmann,Rebecca Smith,Kaylyn Devlin,Mark A. Dane,Daniel Muñoz-Espín,James E. Korkola +6 more
TL;DR: This study identifies senescence-associated drivers of tumour growth and progression using a novel microarray platform, revealing multiple SASP factors that enhance proliferation and cell numbers in breast and lung cancer cells, with implications for targeted therapy.
S-Nitrosylated COX-2 is a microenvironment-regulated breast cancer cell biomarker of mesenchymal phenotypes.
Reuben J. Hoffmann,Ae Soon L. Bensen,Mark A. Dane,Jane Arterberry,Rebecca Smith,James E. Korkola,Pepper Schedin +6 more
Abstract IA034: Compromised myoepithelial cell differentiation correlates with DCIS to IDC transition
Sarah M. Bernhardt,Elizabeth Mitchell,Tanya D. Russell,Sonali Jindal,Jayasri Narasimhan,Reuben J. Hoffmann,AeSoon Benson,Pepper Schedin +7 more
TL;DR: Bernhardt et al. as discussed by the authors investigated whether changes in myoepithelial cell differentiation, rather than overt cell loss, associate with DCIS tumor cell dissemination, and found that compromised my oepithelium correlates with microinvasion and an immune infiltrate enriched in PD1+CD8 T cells.
Abstract 5504: A tumor-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer
Estela Gonzalez-Gualda,David Macías,Samir Morsli,Jose Ezequiel Martin,Hui-Ling Ou,M. Denholm,Ioana Olan,Reuben J. Hoffmann,Mark A. Dane,Dimitris Veroutis,Guillermo Medrano,Francisca Mulero,Carla P. Martins,Mariano Barbacid,Vassilis G. Gorgoulis,James E. Korkola,Doris Rassl,Gary J. Doherty,Robert C. Rintoul,Masashi Narita,Daniel Muñoz-Espín +20 more
TL;DR: Gualda et al. as mentioned in this paper showed that adding TGFBR1 inhibitors to platinum-based chemotherapy reduces tumor burden and improves survival, providing pre-clinical proof-of-concept for future trial designs on combination therapies.