Reshad Dobardzic
Washington University in St. Louis
5 Papers
198 Citations
Reshad Dobardzic is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Ancylostoma & Hookworm vaccine. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Reshad Dobardzic include George Washington University.
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Papers
Cloning, yeast expression, isolation, and vaccine testing of recombinant Ancylostoma-secreted protein (ASP)-1 and ASP-2 from Ancylostoma ceylanicum.
Gaddam Goud,Bin Zhan,Kashinath Ghosh,Alex Loukas,John M. Hawdon,Azra Dobardzic,Vehid Deumic,Sen Liu,Reshad Dobardzic,Bernard C. Zook,Qun Jin,Yueyuan Liu,Laura Hoffman,Sophia Chung-Debose,Rachna Patel,Susana Mendez,Peter J. Hotez +16 more
TL;DR: Results indicate that ASP-2 is a promising molecule for the development of a hookworm vaccine and Splenomegaly, which was observed in control hamsters, was not seen in hamsters vaccinated with either irL3 or ASP- 2 formulated with Quil A.
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Effect of Vaccination with a Recombinant Fusion Protein Encoding an Astacinlike Metalloprotease (MTP-1) Secreted by Host-Stimulated Ancylostoma caninum Third-Stage Infective Larvae
Peter J. Hotez,James Ashcom,Bin Zhan,Jeffrey M. Bethony,Alex Loukas,John M. Hawdon,Yang Wang,Qun Jin,Karen Jones,Azra Dobardzic,Reshad Dobardzic,Janelle Bolden,Idong Essiet,Walter E. Brandt,Philip K. Russell,Bernard C. Zook,Brian E. Howard,Marco Chacon +17 more
TL;DR: Spearman rank order correlations between the canine intestinal adult hookworm burden and quantitative egg counts at necropsy and anti-Ac-MTP-1 IgG2 antibody titers revealed a statistically significant inverse association, suggesting that this molecule offers promise as a recombinant vaccine.
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Effect of vaccinations with recombinant fusion proteins on Ancylostoma caninum habitat selection in the canine intestine.
Peter J. Hotez,James Ashcom,Zhan Bin,Jeffrey M. Bethony,Angela L. Williamson,John M. Hawdon,Feng Jianjun,Azra Dobardzic,Ivania Rizo,Janelle Bolden,Qun Jin,Wang Yan,Reshad Dobardzic,Sophia Chung-Debose,Melissa Crowell,Bennett J. D. Datu,Angela Delaney,Dilyan Dragonovski,Yang Jiang,Liu Yueyuan,Kashinath Ghosh,Alex Loukas,Walter E. Brandt,Philip K. Russell,Bernard C. Zook +24 more
TL;DR: Anti-enzyme and anti-en enzyme inhibitor antibodies correlated with an alteration in adult hookworm habitat selection in the canine gastrointestinal tract.
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Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative.
Peter J. Hotez,Bin Zhan,Jeffrey M. Bethony,Alex Loukas,Angela L. Williamson,Gaddam Goud,John M. Hawdon,Azra Dobardzic,Reshad Dobardzic,Kashinath Ghosh,Maria Elena Bottazzi,Susana Mendez,Bernard C. Zook,Yan Wang,Sen Liu,Sen Liu,Idong Essiet-Gibson,Sophia Chung-Debose,Shu-Hua Xiao,David P. Knox,Michael M. Meagher,Mehmet Inan,Rodrigo Correa-Oliveira,Paul Vilk,Herman R Shepherd,Walter E. Brandt,Philip K. Russell +26 more
TL;DR: Despite the inability of the human host to develop naturally acquired immune responses to hookworm, there is evidence for the feasibility of developing a vaccine based on the successes of immunising laboratory animals with either attenuated larval vaccines or antigens extracted from the alimentary canal of adult blood-feeding stages
Effect of combining the larval antigens Ancylostoma secreted protein 2 (ASP-2) and metalloprotease 1 (MTP-1) in protecting hamsters against hookworm infection and disease caused by Ancylostoma ceylanicum.
Susana Mendez,Bin Zhan,Gaddam Goud,Kashinath Ghosh,Azra Dobardzic,Wenhui Wu,Sen Liu,Vehid Deumic,Reshad Dobardzic,Yueyuan Liu,Jeffrey M. Bethony,Peter J. Hotez +11 more
TL;DR: Data suggest that combination of two or more antigens may present an effective vaccine development strategy to improve protection and/or disease symptoms in affected individuals.