Renato Gennaro
University of Trieste
106 Papers
802 Citations
Renato Gennaro is an academic researcher from University of Trieste. The author has contributed to research in topics: Antimicrobial peptides & Cathelicidin. The author has an hindex of 50, co-authored 104 publications. Previous affiliations of Renato Gennaro include Centre national de la recherche scientifique & University of Udine.
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Papers
Role of Cathelicidin Peptides in Bovine Host Defense and Healing
Linda Tomasinsig,Monica Benincasa,Marco Scocchi,Barbara Skerlavaj,Alessandro Tossi,Margherita Zanetti,Renato Gennaro +6 more
TL;DR: The results suggest that the broad-spectrum activity of BMAP-28 correlates with a high capacity to interact with and permeabilize bacterial membranes, whereas the proline-rich AMPs selectively internalize into the cytoplasm of susceptible Gram-negative bacteria with a non-lytic mechanism.
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Investigating the mode of action of proline-rich antimicrobial peptides using a genetic approach: a tool to identify new bacterial targets amenable to the design of novel antibiotics.
Marco Scocchi,Maura Mattiuzzo,Monica Benincasa,Nikolinka Antcheva,Alessandro Tossi,Renato Gennaro +5 more
TL;DR: Several genes that are involved in the mechanism of action of these peptides, including peptide-transport systems or potential resistance factors, which can be used or taken into account in drug design efforts are identified.
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Small, antibacterial and large, inactive peptides of neutrophil granules share immunoreactivity to a monoclonal antibody.
Roberto Marzari,Bruna Scaggiante,Barbara Skerlavaj,Manuela Bittolo,Renato Gennaro,Domenico Romeo +5 more
TL;DR: Monoclonal antibodies were raised against a bactericidal protein fraction that was purified from an extract of bovine neutrophil granules and that was previously shown to inhibit bacterial DNA synthesis, and one of these antibodies, BP97, was covalently linked to Affi-Gel 10 and was used for immunoaffinity chromatography of granule extracts.
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C-reactive protein decreases protein phosphorylation in stimulated human neutrophils
TL;DR: Contrary to the effects exerted on protein phosphorylation, CRP does not affect the fMLF‐elicited increase in neutrophil cytosolic Ca2+.
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Sensitivity of Chlamydia suis to cathelicidin peptides.
Manuela Donati,Antonietta Di Francesco,Renato Gennaro,Monica Benincasa,Simone Magnino,Salvatore Pignanelli,Alisa Shurdhi,Alessandra Moroni,Claudio Mazzoni,Giuseppe Merialdi,Raffaella Baldelli,Roberto Cevenini +11 more
TL;DR: Nine Chlamydia suis isolates, obtained from pigs with conjunctivitis, were molecularly characterized by ompA sequencing and their in vitro susceptibility to six cathelicidin peptides determined in cell culture and SMAP-29 was the most active peptide.
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