173 Papers
1.4K Citations
Renate Kunert is an academic researcher from University of Natural Resources and Life Sciences, Vienna. The author has contributed to research in topics: Chinese hamster ovary cell & Monoclonal antibody. The author has an hindex of 47, co-authored 170 publications. Previous affiliations of Renate Kunert include University of Agriculture, Faisalabad & University of Agricultural Sciences, Dharwad.
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Papers
Antibody Domain Exchange Is an Immunological Solution to Carbohydrate Cluster Recognition
Daniel A. Calarese,Christopher N. Scanlan,Michael B. Zwick,Songpon Deechongkit,Yusuke Mimura,Renate Kunert,Ping Zhu,Mark R. Wormald,Robyn L. Stanfield,Kenneth H. Roux,Jeffery W. Kelly,Pauline M. Rudd,Raymond A. Dwek,Hermann Katinger,Dennis R. Burton,Ian A. Wilson +15 more
TL;DR: The extraordinary configuration of this antibody provides an extended surface, with newly described binding sites, for multivalent interaction with a conserved cluster of oligomannose type sugars on the surface of gp120, finding a previously unappreciated mechanism for high-affinity recognition of carbohydrate or other repeating epitopes on cell or microbial surfaces.
878
Cardiolipin Polyspecific Autoreactivity in Two Broadly Neutralizing HIV-1 Antibodies
Barton F. Haynes,Judith A. Fleming,E. William St. Clair,Herman Katinger,Gabriela Stiegler,Renate Kunert,James E. Robinson,Richard M. Scearce,Kelly Plonk,Herman F. Staats,Thomas L. Ortel,Hua-Xin Liao,S. Munir Alam +12 more
TL;DR: It is demonstrated that the two most broadly reactive HIV-1 envelope gp41 human mAbs, 2F5 and 4E10, are polyspecific autoantibodies reactive with the phospholipid cardiolipin, which may have important implications for generating effective neutralizing antibody responses by using HIV- 1 vaccines.
794
Advances in recombinant antibody manufacturing
Renate Kunert,David Reinhart +1 more
TL;DR: CHO cells are the most frequently investigated cell lines and remain the workhorse for monoclonal antibody (mAb) expression until today.
Analysis of immunoglobulin glycosylation by LC-ESI-MS of glycopeptides and oligosaccharides.
Johannes Stadlmann,Martin Pabst,Daniel Kolarich,Daniel Kolarich,Renate Kunert,Friedrich Altmann +5 more
TL;DR: They both outperform non‐MS methods in terms of reliability of peak assignment and MALDI‐MS of underivatized glycans with regard to the recording of sialylated structures and Regarding fast and yet detailed structural assignment, LC‐MS on graphitic carbon supersedes all other current methods.
351
Anti-Human Immunodeficiency Virus Type 1 (HIV-1) Antibodies 2F5 and 4E10 Require Surprisingly Few Crucial Residues in the Membrane-Proximal External Region of Glycoprotein gp41 To Neutralize HIV-1
Michael B. Zwick,Richard Jensen,Sarah E. Church,Min Wang,Gabriela Stiegler,Renate Kunert,Hermann Katinger,Dennis R. Burton +7 more
TL;DR: The data suggest that MPER substitutions can act locally and enhance the neutralizing activity of antibodies to this region and imply a distinct role of the MPER of gp41 during HIV-1 envelope-mediated fusion.
317