Renata Culak
Health Protection Agency
7 Papers
125 Citations
Renata Culak is an academic researcher from Health Protection Agency. The author has contributed to research in topics: Biology & Proteome. The author has an hindex of 5, co-authored 7 publications. Previous affiliations of Renata Culak include Nottingham Trent University.
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Papers
High throughput identification of clinical isolates of Staphylococcus aureus using MALDI-TOF-MS of intact cells.
Lakshani Rajakaruna,Gillian Hallas,Linda Molenaar,Diane Dare,Helen Sutton,Vesela Encheva,Renata Culak,Ingrid Innes,Graham Ball,Armine Sefton,Melvin Eydmann,Angela M. Kearns,Haroun N. Shah +12 more
TL;DR: MALDI-TOF-MS has the potential to perform high throughput identification of clinical isolates of S. aureus despite the inherent diversity of this species, but is only reproducible if variable parameters such as sample preparation, media, growth condition, etc. are standardised.
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New approaches to identification of bacterial pathogens by surface enhanced laser desorption/ionization time of flight mass spectrometry in concert with artificial neural networks, with special reference to Neisseria gonorrhoeae.
TL;DR: The application of SELDI-TOF MS in concert with a multi-layer perceptron artificial neural network (ANN) with a back propagation algorithm for the identification of Neisseria gonorrhoeae, the second most common sexually transmitted disease in the UK and USA is described.
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Comparative analysis of virulence determinants and mass spectral profiles of Finnish and Lithuanian endodontic Enterococcus faecalis isolates
A. H. Reynaud Af Geijersstam,Renata Culak,Linda Molenaar,Marie Anne Chattaway,E. Røslie,V. Peciuliene,Markus Haapasalo,Haroun N. Shah +7 more
TL;DR: A high prevalence of virulence factors was demonstrated in both population types and SELDI-TOF-MS and MALDI-TFO-MS proved useful in distinguishing between different E. faecalis phenotypes and they may be useful technologies for elucidating the eco-distribution of E. Faecalis in humans.
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Correlation between Phylogroups and Intracellular Proteomes of Propionibacterium acnes and Differences in the Protein Expression Profiles between Anaerobically and Aerobically Grown Cells
TL;DR: Good congruence between genomic and proteomic data is revealed suggesting that the microenvironment of each subtype may influence protein expression in P. acnes, indicating that the species consists of three major evolutionary clades.
Minor Differences in the Proteome of Bacillus subtilis and Bacillus mojavensis Based upon High Abundance/ Conserved Protein MassSpectra; Implications for Rapid, Improved Identification of Two Pathogen Genetically Closely Related
Timothy Chambers,Renata Culak,Saheer E. Gharbia,Haroun N Shah +3 more
- 01 Jan 2015
TL;DR: It is demonstrated unequivocally that Bacillus species may be reliably identified using this approach prior to sporulation, and minor components of the mass spectrum were teased out that enabled unambiguous separation of both groups of strains.
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