The present disclosure relates to antibodies and antigen-binding portions thereof that specifically bind to a M-CSF, preferably human M-CSF, and that function to inhibit a M-CSF. The disclosure also relates to human anti-M-CSF antibodies and antigen-binding portions thereof. The disclosure also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The disclosure also relates to isolated heavy and light chain immunoglobulins derived from human anti-M-CSF antibodies and nucleic acid molecules encoding such immunoglobulins. The present disclosure also relates to methods of making human anti-M-CSF antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The disclosure also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-M-CSF antibodies. The disclosure also relates to transgenic animals and transgenic plants comprising nucleic acid molecules of the present disclosure.

Antibodies to m-csf

It is intended to provide a method whereby a plural number of antibodies against cell surface antigens are quickly classified and to provide a method whereby antigens of the thus classified antibodies are quickly identified. Further, it is intended to provide a method of promoting the utilization of the useful data obtained by the above methods. Furthermore, it is intended to provide an antibody which is effective in treating or diagnosing cancer. Namely, a method of classifying antibodies which comprises: (1) the step of preparing a plural number of antibodies respectively recognizing cell surface antigens; (2) the step of bringing each of these antibodies into contact with a cell of the same species; (3) the step of analyzing each of the cells having been treated in the step (2) by flow cytometry and thus obtaining data indicating the reactivity of each antibody with its cell surface antigen; and (4) the step of comparing the thus obtained data and classifying the individual antibodies depending on the similarity. A method of identifying antigens which further comprises: (5) the step of selecting one to several antibodies from each antibody group formed in the step (4) and identifying antigens thereof; and (6) on the assumption that antigens of the antibodies belonging to a single antibody group are the same or highly related to one another, making relations between the antigens having been identified in the step (5) and the antibody groups to thereby identify the antigens. An antibody against HER1, an antibody against HER2, an antibody against CD46, an antibody against ITGA3, an antibody against ICAM1, an antibody against ALCAM, an antibody against CD147, an antibody against C1qR, an antibody against CD44, an antibody against CD73, an antibody against EpCAM and an antibody against HGFR, each obtained by using the above methods.

Method of classifying antigen, method of identifying antigen, method of obtaining antibody or antibody set, method of constructing antibody panel and antibody or antibody set and use of the same

The present application is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease The present application provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins The antibodies enabled by the teaching of the present application are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD)

Monoclonal anti beta amyloid antibody

It is intended to provide a method whereby a membrane protein occurring in cell membrane can be conveniently, quickly and highly accurately quantified by mass spectrometry with the use of a stable isotope-labeled peptide as a probe. This method comprises: fragmenting a cell membrane protein into oligopeptide fragments; identifying them by LC-MSMS; selecting peptides obtained by using a protease and a peptide specific for the target molecule as essential criteria; setting scored criteria for selection considering hydrophobic amino acid content, sequential conditions, amino acid residue count, specific amino acid sequential conditions and so on; selecting a peptide fragment, which can be ionized by the ESI method, in accordance with the criteria for selecting the target peptide to be quantified whereby a peptide having a higher total score is preferentially selected; and thus quantifying the cell membrane protein at a high accuracy by mass spectrometry with the use of the target peptide to be quantified and the stable isotope-labeled peptide.

Method of Quantifying Membrane Protein By Using Mass Spectrometer

The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease. The present invention provides novel methods and compositions comprising highly specific and highly effective antibodies having the ability to specifically recognize and bind to specific epitopes from a range of β-amyloid proteins. The antibodies enabled by the teaching of the present invention are particularly useful for the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD).

Monoclonal antibodies that recognize epitopes of amyloid-beta

A method for screening an antibody that binds to a cell surface antigen is provided. The present invention provides a method for screening an antibody that binds to a cell surface antigen having the following characteristics. Washing the antigen-antibody complex in a low-polarity solvent Antigen-antibody reaction in the presence of an already obtained antibody (or an antigen to which it binds) Further, the present invention is useful for the screening of antibodies. A method for producing a fraction is provided. The soluble fraction obtained by the present invention is also useful for the isolation of cell surface antigens recognized by antibodies. [Selection figure] None

Acquisition of antibody to cell surface antigen and method for identification of the antigen

PROBLEM TO BE SOLVED: To provide an antibody capable of specifically recognizing the transferrin receptor of a protein which is expressed in ATL cells.SOLUTION: An antibody includes a heavy chain variable region having a specific amino acid sequence as defined in the present specification and a light chain variable region having a specific amino acid sequence as defined in the present specification and specifically binds to TfR.

Transferrin receptor antibody

PROBLEM TO BE SOLVED: To provide means for rapidly classifying a plurality of human antibodies and antigens against cell surface antigens to provide antibodies useful for the treatment and diagnosis of cancer.SOLUTION: The invention relates to human antibodies having a specific binding property to CD73 comprising a heavy chain variable region CDR1 to CDR3 and a light chain variable region CDR1 to CDR3, defined by a specific combination of sequence numbers.SELECTED DRAWING: None

Antibody and application thereof

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Acquisition of antibody to cell surface antigen and method for identification of the antigen

Transferrin receptor antibody

Antibody and application thereof

仁 黒澤

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Papers

Acquisition of antibody to cell surface antigen and method for identification of the antigen

Transferrin receptor antibody

Antibody and application thereof

仁黒澤