抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

http://talklab.psy.gla.ac.uk/KeepItMaximalR2.pdf

Random effects structure for confirmatory hypothesis testing: Keep it maximal

because observed behavior is the result of interactions between environmental factors and genes during the extended period of development. Therefore, to better understand expert and exceptional performance, we must require that the account specify the different environmental factors that could selectively promote and facilitate the achievement of such performance. In addition, recent research on expert performance and expertise (Chi, Glaser, & Farr, 1988; Ericsson & Smith, 1991a) has shown that important characteristics of experts' superior performance are acquired through experience and that the effect of practice on performance is larger than earlier believed possible. For this reason, an account of exceptional performance must specify the environmental circumstances, such as the duration and structure of activities, and necessary minimal biological attributes that lead to the acquisition of such characteristics and a corresponding level of performance. An account that explains how a majority of individuals can attain a given level of expert performance might seem inherently unable to explain the exceptional performance of only a small number of individuals. However, if such an empirical account could be empirically supported, then the extreme characteristics of experts could be viewed as having been acquired through learning and adaptation, and studies of expert performance could provide unique insights into the possibilities and limits of change in cognitive capacities and bodily functions. In this article we propose a theoretical framework that explains expert performance in terms of acquired characteristics resulting from extended deliberate practice and that limits the role of innate (inherited) characteristics to general levels of activity and emotionality. We provide empirical support from two new studies and from already published evidence on expert performance in many different domains.

/pdf/the-role-of-deliberate-practice-in-the-acquisition-of-expert-3j9768t5su.pdf

The role of deliberate practice in the acquisition of expert performance.

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Modern Applied Statistics With S

https://www.sfs.uni-tuebingen.de/~hbaayen/publications/baayenDavidsonBates.pdf

Mixed-effects modeling with crossed random effects for subjects and items

Primary saccades are often followed by small secondary saccades, which are generally thought to reduce the distance between the saccade endpoint and target location. Accumulated evidence demonstrates that secondary saccades are subject to various influences, among which retinal feedback during postsaccadic fixation constitutes only one important signal. Recently, we reported that target eccentricity and an orientation bias influence the generation of secondary saccades. In the present study, we examine secondary saccades in the absence of postsaccadic visual feedback. Although extraretinal signals (e.g., efference copy) have received widespread attention in eye-movement studies, it is still unclear whether an extraretinal error signal contributes to the programming of secondary saccades. We have observed that secondary saccade latency and amplitude depend on primary saccade error despite the absence of postsaccadic visual feedback. Strong evidence for an extraretinal error signal influencing secondary saccade programming is given by the observation that secondary saccades are more likely to be oriented in a direction opposite to the primary saccade as primary saccade error shifts from target undershoot to overshoot. We further show how the functional relationship between primary saccade landing position and secondary saccade characteristics varies as a function of target eccentricity. We propose that initial target eccentricity and an extraretinal error signal codetermine the postsaccadic activity distribution in the saccadic motor map when no visual feedback is available.

The generation of secondary saccades without postsaccadic visual feedback.

Publisher Summary
SWIFT is a computational model of eye guidance in reading. The model accounts for fixation probabilities as well as various measures of inspection time in their relation to lexical processing difficulty. A word is processed as soon as it is within the perceptual span, leading to a dynamic change in what is called “lexical activity” associated with this word. It is assumed that there is a maximum of lexical activity with each word, depending on its frequency and predictability from the prior sentence context. The SWIFT model can be used to predict typical measures used for the analysis of eye movement experiments with gaze-contingent display changes. The influence of preview manipulations and the mechanism of extraction of information to the left of the fixated word are qualitatively in good agreement with experimental results. These results underline the model's psychological plausibility and explain the way properties of the perceptual window can be thought to influence the dynamics of eye movements.

Chapter 19 – SWIFT Explorations

It is well established that fixation durations during reading vary with processing difficulty, but there are different views on how oculomotor control, visual perception, shifts of attention, and lexical (and higher cognitive) processing are coordinated. Evidence for a one-to-one translation of input delay into saccadic latency would provide a much needed constraint for current theoretical proposals. Here, we tested predictions of such a direct-control perspective using the stimulus-onset delay (SOD) paradigm. Words in sentences were initially masked and, on fixation, were individually unmasked with a delay (0-, 33-, 66-, 99-ms SODs). In Experiment 1, SODs were constant for all words in a sentence; in Experiment 2, SODs were manipulated on target words, while nontargets were unmasked without delay. In accordance with predictions of direct control, nonzero SODs entailed equivalent increases in fixation durations in both experiments. Yet, a population of short fixations pointed to rapid saccades as a consequence of low-level information at nonoptimal viewing positions rather than of lexical processing. Implications of these results for theoretical accounts of oculomotor control are discussed.

Evidence for direct control of eye movements during reading

This study investigates the eye movements of dyslexic children and their age-matched controls when reading Chinese. Dyslexic children exhibited more and longer fixations than age-matched control children, and an increase of word length resulted in a greater increase in the number of fixations and gaze durations for the dyslexic than for the control readers. The report focuses on the finding that there was a significant difference between the two groups in the first-fixation landing position as a function of word length in single-fixation cases, while there was no such difference in the initial fixation of multi-fixation cases. We also found that both groups had longer incoming saccade amplitudes while the launch sites were closer to the word in single fixation cases than in multi-fixation cases. Our results suggest that dyslexic children's inefficient lexical processing, in combination with the absence of orthographic word boundaries in Chinese, leads them to select saccade targets at the beginning of words conservatively. These findings provide further evidence for parafoveal word segmentation during reading of Chinese sentences. Vision Research

Saccade-Target Selection of Dyslexic Children When Reading Chinese

The lexical database dlexDB supplies in form of an online database frequency-based norms of numerous process-related word properties for psychological and linguistic research. These values include well known variables such as printed frequency of word form and lemma as documented also in CELEX (Baayen, Piepenbrock und Gulikers, 1995). In addition, we compute new values like frequencies based on syllables, and morphemes as well as frequencies of character chains, and multiple word combinations. The statistics are based on the Kernkorpus des Digitalen Wrterbuchs der deutschen Sprache (DWDS) with over 100 million running words. We illustrate the validity of these norms with new results about fixation durations in sentence reading.

dlexDB - A lexical database for the psychological and linguistic research

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