Regula Furrer
University of Basel
17 Papers
6 Citations
Regula Furrer is an academic researcher from University of Basel. The author has contributed to research in topics: Skeletal muscle & Inflammation. The author has an hindex of 8, co-authored 17 publications.
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Papers
Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance.
Leandro Z. Agudelo,Leandro Z. Agudelo,Duarte M. S. Ferreira,Shamim Dadvar,Igor Cervenka,Lars Ketscher,Manizheh Izadi,Liu Zhengye,Regula Furrer,Christoph Handschin,Tomas Venckunas,Marius Brazaitis,Sigitas Kamandulis,Johanna T. Lanner,Jorge L. Ruas +14 more
TL;DR: It is shown that PGC-1α1 activates the malate-aspartate shuttle, and allows muscle to utilise kynurenine, leading to more efficient glucose oxidation and mitochondrial respiration, and may have important physiological and clinical implications.
Muscle Wasting Diseases: Novel Targets and Treatments.
TL;DR: An overview of the current knowledge of the key mechanisms involved in muscle wasting conditions and novel pharmacological avenues that could ameliorate muscle diseases is provided.
The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo.
TL;DR: The anti-inflammatory environment in muscle that is promoted by the PGC-1s might contribute to the beneficial effects of these coactivators on muscle function and provides a molecular link underlying the tight mutual regulation of metabolism and inflammation.
71
PGC-1α modulates necrosis, inflammatory response, and fibrotic tissue formation in injured skeletal muscle
Ivana Dinulovic,Regula Furrer,Sabrina Di Fulvio,Arnaud Ferry,Markus Beer,Christoph Handschin +5 more
TL;DR: Interestingly, PGC-1α-dependent effects at the early stages of regeneration are observed, in particular regarding macrophage accumulation and polarization from the pro- inflammatory M1 to the anti-inflammatory M2 type, a faster resolution of necrosis and protection against the development of fibrosis after multiple CTX-induced injuries.
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Paracrine cross-talk between skeletal muscle and macrophages in exercise by PGC-1α-controlled BNP
TL;DR: It is demonstrated that besides a dominant role in controlling cellular metabolism, the peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) also has a profound effect on cytokine expression in muscle tissue.