Regine Goth-Goldstein
University of California, Berkeley
6 Papers
133 Citations
Regine Goth-Goldstein is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Chinese hamster ovary cell & Nucleotide excision repair. The author has an hindex of 5, co-authored 6 publications. Previous affiliations of Regine Goth-Goldstein include University of California, San Francisco.
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Papers
Oxidative stress induced by zero-valent iron nanoparticles and Fe(II) in human bronchial epithelial cells.
TL;DR: The role of reactive oxidants produced during Fe( II) oxidation in cytotoxicity and internal ROS production is supported by experiments in which cell damage was limited by the addition of ligands that prevented Fe(II) oxidation and by the absence of cell damage when the nanoparticles were oxidized prior to exposure.
Recruitment of cell phospholipids and cholesterol by apolipoproteins A-II and A-I: formation of nascent apolipoprotein-specific HDL that differ in size, phospholipid composition, and reactivity with LCAT.
TL;DR: It is demonstrated, for the first time, that apoA-II and apo-I show a preference in phospholipid recruitment from membranes.
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Repair of DNA damaged by alkylating carcinogens is defective in xeroderma pigmentosum-derived fibroblasts.
TL;DR: Direct measurement of the amounts of two products formed by alkylating carcinogens in the DNA and of the rate at which they are eliminated indicates that XP cells have a defect in this type of repair also.
112
Characterization of a CHO variant in respect to alkylating agent-induced biological effects and DNA repair.
TL;DR: It is concluded that the resistant variant has some unknown tolerance mechanism which alters the cytotoxic, but not the SCE- and mutation-inducing effects of methylating N-nitroso compounds.
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Toxicity of 4-nitroquinoline 1-oxide in Chinese hamster ovary cells: Influence of cell density and of position in the cell cycle
TL;DR: When the cell-cycle response for 4-NQO-induced cell killing was measured in synchronous cells, a characteristic age response was seen in wild-type cells with greatly increased sensitivity in late G1 to early S and resistance increasing through the S-phase, appearing to be associated with DNA repair.
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