The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.

Anti-angiogenic compositions and methods of use

The invention relates to the use of an immunogen selected from the group consisting of: (i) a monoclonal antibody (mAb) to a tumor-associated antigen (TAA); (ii) a fragment of a mAb of (i); (iii) a peptide based on a complementarity-determining region (CDR) of the heavy or light chain of said mAb of (i), which peptide is capable of eliciting antibodies to said TAA; and (iv) a DNA molecule coding for the variable (V) region of said mAb of (i) in a suitable gene delivery vehicle, for the preparation of a pharmaceutical composition useful for induction of anti-tumor immunity in mammals, for activing an enhanced immune response to a TAA molecule in mammals, and/or for induction of immune responses to mutated and wild-type forms of a TAA in mammals. The use of anti-p53 mAbs and novel peptides based on the CDR2 and CDR3 of the heavy chains and CDR3 of the light chains of different anti-p53 mAbs are disclosed.

Immunogenic compositions for induction of anti-tumor immunity

PROBLEM TO BE SOLVED: To provide a method for decreasing immunogenicity.SOLUTION: A method for decreasing the immunogenicity of an antibody variable domain is disclosed. The invention provides a method for decreasing the immunogenicity of an antibody variable domain comprising a variable light chain and/or a variable heavy chain. The method comprises the step of substituting one or more amino acid residues of the variable light chain and/or the variable heavy chain, the residue being present at the interface between the variable chain and the constant chain of a corresponding full-length antibody or Fab. In one aspect, the antibody variable domain is an scFv, an Fv fragment or a single domain antibody, in particular an scFv.SELECTED DRAWING: None

Method for decreasing immunogenicity

The present invention is methods and compositions including a photoactivated antibody that is capable of generating or increasing an immune response.

Therapeutic composition and method of treatment

The present invention relates to a simple process for the modification of, e.g., anti-TAA antibodies, which alters their immunogenicity so that their ability to induce an anti-isotypic response is selectively diminished, while they remain able to elecit an anti-idiotypic response. The latter is of potential immunotherapeutic value, i.e., by activation of the idiotype-anti-idiotype network. This modification takes the form of a controlled and partial reduction of the antibody; effector regions are retained. The invention should permit repeat injections (for diagnosis and therapy) and reduce HAMA interference in serodiagnostic assays.

Selective alteration of antibody immunogenicity

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Selective alteration of antibody immunogenicity