Raymond Farley
National Institutes of Health
19 Papers
244 Citations
Raymond Farley is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Genetic enhancement & Cystic fibrosis. The author has an hindex of 15, co-authored 19 publications. Previous affiliations of Raymond Farley include Imperial College London.
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Papers
Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial.
Eric W.F.W. Alton,M Stern,Raymond Farley,Adam Jaffe,Sharon Chadwick,J. Phillips,Jane C. Davies,Stephen N. Smith,JE Browning,Michael G. Davies,Margaret E. Hodson,Stephen R. Durham,D. Li,Peter K. Jeffery,M. Scallan,RP Balfour,Simon J. Eastman,Seng H. Cheng,Alan E. Smith,D. P. Meeker,Duncan M. Geddes +20 more
TL;DR: The safety and efficacy of cationic-lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis was studied in a double-blind placebo-controlled trial.
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Mucus altering agents as adjuncts for nonviral gene transfer to airway epithelium.
Stefano Ferrari,Chris Kitson,Raymond Farley,R Steel,Christopher Marriott,D A Parkins,Maurizio Scarpa,Brandon J. Wainwright,Martin J. Evans,William H. Colledge,Duncan M. Geddes,Ewfw Alton +11 more
TL;DR: In vivo application of either Nacystelyn or the anticholinergic glycopyrrolate, both clinically used agents, resulted in increased reporter gene expression in the mouse lung, but no significant correction of the bioelectric defect in CF null mice.
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Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo
Uta Griesenbach,Chris Kitson,Escudero Sara Garcia,Raymond Farley,Charanjit Singh,Luci Somerton,Hazel Painter,Rbecca L Smith,Deborah R. Gill,Stephen C. Hyde,Yu-Hua Chow,Jim Hu,Michael A. Gray,Mark R. Edbrooke,V. C. Ogilvie,Gordon MacGregor,Ronald K. Scheule,Seng H. Cheng,Natasha J. Caplen,Eric W.F.W. Alton +19 more
TL;DR: This study suggests that although siRNAs and asODNs can be developed to inhibit gene expression in culture systems and certain organs in vivo, barriers to nucleic acid transfer in airway epithelial cells seen with large DNA molecules may also affect the efficiency of in vivo uptake of smallucleic acid molecules.
Use of ultrasound to enhance nonviral lung gene transfer in vivo.
Stefania Xenariou,Uta Griesenbach,Hai-Dong Liang,Hai-Dong Liang,Jie Zhu,Raymond Farley,Lucinda Somerton,Charanjit Singh,Peter K. Jeffery,Stefano Ferrari,Ronald K. Scheule,S H Cheng,Duncan M. Geddes,Martin J. K. Blomley,Eric W.F.W. Alton +14 more
TL;DR: Proof of principle is established that US can increase nonviral gene transfer, in the air-filled murine lung, despite ultrasound being attenuated by air in the lung, sufficient energy penetrates the tissue to increase gene transfer.
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Sendai virus-mediated CFTR gene transfer to the airway epithelium
Stefano Ferrari,Uta Griesenbach,Akihiro Iida,Raymond Farley,A Wright,Jie Zhu,Felix M. Munkonge,Stephen N. Smith,Stephen N. Smith,J You,H Ban,Makoto Inoue,Mario Chan,Charanjit Singh,Bernard Verdon,Barry E. Argent,Brandon J. Wainwright,Peter K. Jeffery,Duncan M. Geddes,David J. Porteous,Stephen C. Hyde,Michael A. Gray,Mamoru Hasegawa,Eric W.F.W. Alton +23 more
TL;DR: This work has identified a novel method to allow the cystic fibrosis transmembrane conductance regulator (CFTR) cDNA sequence to be inserted within SeV (SeV-CFTR).
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