Ravuri S. K. Kishore
Hoffmann-La Roche
27 Papers
106 Citations
Ravuri S. K. Kishore is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Chemistry & Polysorbate. The author has an hindex of 18, co-authored 24 publications. Previous affiliations of Ravuri S. K. Kishore include Folkwang University of the Arts & University of Geneva.
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Papers
The Degradation of Polysorbates 20 and 80 and its Potential Impact on the Stability of Biotherapeutics
Ravuri S. K. Kishore,Sylvia Kiese,Stefan Fischer,Astrid Pappenberger,Ulla Grauschopf,Hanns-Christian Mahler +5 more
TL;DR: End-of-shelf-life shaking of protein formulations showed that the stability of various monoclonal antibodies was, however, not affected, and degradation of polysorbates did not impact the Stability of the different proteins tested in pharmaceutically relevant temperature and storage conditions.
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Degradation of polysorbates 20 and 80: studies on thermal autoxidation and hydrolysis.
Ravuri S. K. Kishore,Astrid Pappenberger,Isabelle Bauer Dauphin,Alfred Ross,Beatrice Buergi,Andreas Staempfli,Hanns-Christian Mahler +6 more
TL;DR: The purpose of this work was to study the mechanistic pathways of degradation of polysorbates (PS) 20 and PS80 in parenteral formulations, and found that PSs degrade mainly via autoxidation and also via hydrolysis at higher temperatures.
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Key interactions of surfactants in therapeutic protein formulations: A review.
TL;DR: The scope of this review is to convey the current understanding of interactions of nonionic surfactants with proteins both at the interface and in solution, with specific focus to their effects on biotherapeutic formulations.
249
Solvent induced polymorphism in supramolecular 1,3,5-benzenetribenzoic acid monolayers.
Lorenz Kampschulte,Markus Lackinger,Anne-Kathrin Maier,Ravuri S. K. Kishore,Stefan Griessl,Michael Schmittel,Wolfgang M. Heckl +6 more
TL;DR: This work presents a scanning tunneling microscopy (STM) based study of benzenetribenzoic acid (BTB) monolayer structures at the liquid-solid interface, finding a 6-fold chicken-wire structure with circular cavities made possible through comparatively strong 2-fold hydrogen bonds between carboxylic groups.
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Thermodynamical Equilibrium of Binary Supramolecular Networks at the Liquid-Solid Interface
Lorenz Kampschulte,Tova L. Werblowsky,Ravuri S. K. Kishore,Michael Schmittel,Wolfgang M. Heckl,Markus Lackinger +5 more
TL;DR: Coadsorption of two different carboxylic acids was studied at the liquid-solid interface in two different solvents resulting in six nondensely packed monolayer phases with different structures and stoichiometries, as revealed by means of scanning tunneling microscopy (STM).
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