Rashmi U. Pathak
Centre for Cellular and Molecular Biology
19 Papers
132 Citations
Rashmi U. Pathak is an academic researcher from Centre for Cellular and Molecular Biology. The author has contributed to research in topics: Nuclear matrix & Chromatin. The author has an hindex of 8, co-authored 14 publications. Previous affiliations of Rashmi U. Pathak include Council of Scientific and Industrial Research & University of Hyderabad.
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Papers
Deterioration of nuclear morphology and architecture: A hallmark of senescence and aging.
TL;DR: In this paper, the authors discuss about the age-related changes in nuclear features and elaborate upon the molecular reasons driving the change, which can be used to examine progression of agerelated diseases and evaluate therapies.
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AAGAG repeat RNA is an essential component of nuclear matrix in Drosophila
Rashmi U. Pathak,Anitha Mamillapalli,Nandini Rangaraj,Ram Parikshan Kumar,Dasari Vasanthi,Krishnaveni Mishra,Rakesh Mishra +6 more
TL;DR: The results reveal the molecular identity of a critical RNA component of the nuclear architecture and point to one of the utilities of the repetitive part of the genome that has accumulated in higher eukaryotes.
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Boundary element-associated factor 32B connects chromatin domains to the nuclear matrix.
TL;DR: It is shown that BEAF is associated with the nuclear matrix and map the domain required for matrix association to the middle region of the protein, which contains a predicted coiled-coil domain with several potential sites for posttranslational modification.
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Nuclear matrix proteome analysis of Drosophila melanogaster
TL;DR: A subset of NuMat proteins remains associated with the mitotic chromosomes, implicating their role in mitosis and possibly the epigenetic cellular memory, and NuMat proteome analysis provides tools and opens up ways to understand nuclear organization and function.
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Genome-wide mapping of matrix attachment regions in Drosophila melanogaster
TL;DR: The data reveal the contact points of genome to the nuclear architecture and provide a link between nuclear functions and genomic packaging and identify sequence motifs and repeats that constitute MARs.