Rashmi K. Ambasta
Delhi Technological University
71 Papers
62 Citations
Rashmi K. Ambasta is an academic researcher from Delhi Technological University. The author has contributed to research in topics: Neurodegeneration & Medicine. The author has an hindex of 20, co-authored 56 publications. Previous affiliations of Rashmi K. Ambasta include Boston Biomedical Research Institute & Department of Biotechnology.
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Papers
Artificial intelligence to deep learning: machine intelligence approach for drug discovery.
TL;DR: In this article, Artificial Neural Networks and deep learning algorithms have been implemented in several drug discovery processes such as peptide synthesis, structure-based virtual screening, ligand-based screening, toxicity prediction, drug monitoring and release, pharmacophore modeling, quantitative structure-activity relationship, drug repositioning, polypharmacology, and physiochemical activity.
Direct Interaction of the Novel Nox Proteins with p22phox Is Required for the Formation of a Functionally Active NADPH Oxidase
Rashmi K. Ambasta,Pravir Kumar,Kathy K. Griendling,Harald H.H.W. Schmidt,Rudi Busse,Ralf P. Brandes +5 more
TL;DR: Evidence is provided that p22phox directly interacts with Nox1 and Nox4, to form an superoxide-generating NADPH oxidase and it is demonstrated that mutation of the potential heme binding site in the Nox proteins disrupts the complex formation of Nox 1 and NOx4 with p 22phox.
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•Journal Article
p38 MAPK and PI3K/AKT Signalling Cascades in Parkinson's Disease
TL;DR: Many established mechanisms involving the p38 MAPK and PI3K/AKT pathways which can offer therapeutic windows for the rectification of aberrant DA neuronal dynamics in PD brains are outlined.
Linking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration.
TL;DR: The pertinent role of MetS induced mitochondrial dysfunction in neurons and their consequences in NDDs is elucidated and therapeutic potential of well-known biomolecules and chaperones to target altered mitochondria has been comprehensively documented.
106
Autophagy and apoptosis cascade: which is more prominent in neuronal death?
TL;DR: In this paper, the potential role of micro-RNAs, long non-coding RNAs, and biomolecules as therapeutic agents that regulate cell death machinery to treat neurodegenerative diseases.
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