Rasa Elmentaite

TL;DR: An immune cell atlas of human innate and adaptive immune cells across lymphoid, mucosal, and exocrine sites reveals tissue-specific compositions and features, and reveals insights into how the immune system adapts to function effectively in different organ contexts.

TL;DR: The cellular landscape of the human intestinal tract is dynamic throughout life, developing in utero and changing in response to functional requirements and environmental exposures as discussed by the authors, using single-cell RNA sequencing and antigen receptor analysis of almost half a million cells from up to 5 anatomical regions of the developing and up to 11 distinct anatomical regions in the healthy human gut.

TL;DR: An in-depth single-cell map of the developing human intestine at 6–10 weeks post-conception is generated, revealing the transcriptional profile of cycling epithelial precursor cells; distinct from LGR5-expressing cells.

TL;DR: A comprehensive single-cell RNA sequencing atlas of human developing immune system is performed together with antigen-receptor sequencing and spatial transcriptomics to reconstruct the developing human immune system and identifies, characterised and functionally validated the properties of human prenatal B1 cells and the origin of unconventional T cells.