Raphael Serruya
Hebrew University of Jerusalem
10 Papers
19 Citations
Raphael Serruya is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: RNase P & Biology. The author has an hindex of 4, co-authored 7 publications.
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Papers
Human RNase P ribonucleoprotein is required for formation of initiation complexes of RNA polymerase III
Raphael Serruya,Natalie Orlovetskie,Robert Reiner,Yana Dehtiar-Zilber,Donna Wesolowski,Sidney Altman,Nayef Jarrous +6 more
TL;DR: The results demonstrate that the structural intactness, but not the endoribonucleolytic activity per se, of RNase P is critical for the function of Pol III in cells and in extracts.
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A role of human RNase P subunits, Rpp29 and Rpp21, in homology directed-repair of double-strand breaks
Enas R Abu-Zhayia,Hanan Khoury-Haddad,Noga Guttmann-Raviv,Raphael Serruya,Nayef Jarrous,Nabieh Ayoub +5 more
TL;DR: It is demonstrated that Rpp29 and Rpp21 depletion impairs double-strand break (DSB) repair by homology-directed repair (HDR), but has no deleterious effect on the integrity of non-homologous end joining.
A mutation in POLR3E impairs antiviral immune response and RNA polymerase III.
Aravind Ramanathan,Michael Weintraub,Natalie Orlovetskie,Raphael Serruya,Dhivakar Mani,Orly Marcu,Polina Stepensky,Yiska Weisblum,Esther Djian,Avraham Shaag,Shoshana Revel-Vilk,Iris Fried,Moshe Kotler,Alexander Rouvinski,Dana G. Wolf,Orly Elpeleg,Nayef Jarrous +16 more
TL;DR: A rare homozygous mutation (D40H) in the POLR3E gene is described, coding for a protein subunit of Pol III, in a child with disseminated viral infections and Langerhans cell histiocytosis, related to diminished interferon induction and increased cell susceptibility to infection by cytomegalovirus.
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Glutamate catabolism during sporulation determines the success of the future spore germination
TL;DR: In this paper , the metabolic enzyme RocG catabolizes glutamate, facilitating ATP production in the spore progenitor cell, and subsequently influencing the eventual spore ATP reservoir.
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Targeted inhibition of WRN helicase, replication stress and cancer.
TL;DR: New evidence is presented that WRN depletion results in early changes of RNA polymerase III and RNase P activities, thereby implicating chromatin-associated tRNA enzymes in WRN-related stress response and supporting the targeting prospect of these genome guardians.
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