Raphaël Beck
Université catholique de Louvain
14 Papers
81 Citations
Raphaël Beck is an academic researcher from Université catholique de Louvain. The author has contributed to research in topics: Oxidative stress & Cancer cell. The author has an hindex of 12, co-authored 14 publications.
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Papers
Overexpression of GRP94 in breast cancer cells resistant to oxidative stress promotes high levels of cancer cell proliferation and migration: Implications for tumor recurrence
Nicolas Dejeans,Christophe Glorieux,Samuel Guenin,Raphaël Beck,Brice Sid,Réjane Rousseau,Bettina Bisig,Philippe Delvenne,Pedro Buc Calderon,Pedro Buc Calderon,Julien Verrax +10 more
TL;DR: This study suggests that GRP94 overexpression may be a hallmark of aggressiveness and recurrence in breast cancers.
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Endoplasmic reticulum calcium release potentiates the ER stress and cell death caused by an oxidative stress in MCF-7 cells
Nicolas Dejeans,Nicolas Tajeddine,Raphaël Beck,Julien Verrax,Henryk Taper,Philippe Gailly,Pedro Buc Calderon,Pedro Buc Calderon +7 more
TL;DR: Using microspectrofluorimetry, it is demonstrated that Asc/Men-generated oxidative stress was associated with a slow and moderate increase in [Ca2+](c), largely preceding permeation of propidium iodide, and thus cell death, supporting a role of ER stress in the process of Asc/ men cytotoxicity.
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Hsp90 cleavage by an oxidative stress leads to its client proteins degradation and cancer cell death.
Raphaël Beck,Julien Verrax,Thomas Gonze,Marianne Zappone,Rozangela Curi Pedrosa,Henryk Taper,Olivier Feron,Pedro Buc Calderon +7 more
TL;DR: It is shown that different Hsp90 client proteins like Bcr-Abl (a chimerical protein expressed in K562 leukemia cells), RIP and Akt, were degraded when K562 cells were exposed to an oxidative stress, leading to the degradation of some critical proteins and cell death.
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Hsp90 Is Cleaved by Reactive Oxygen Species at a Highly Conserved N-Terminal Amino Acid Motif
Raphaël Beck,Nicolas Dejeans,Christophe Glorieux,Mélanie Creton,Edouard Delaive,Marc Dieu,Martine Raes,Philippe Levêque,Bernard Gallez,Matthieu Depuydt,Jean-François Collet,Pedro Buc Calderon,Pedro Buc Calderon,Julien Verrax +13 more
TL;DR: It is demonstrated that free radicals formed during oxidative stress conditions can cleave Hsp90 through a Fenton reaction which requires the presence of redox-active iron.
Redox-active quinones and ascorbate: an innovative cancer therapy that exploits the vulnerability of cancer cells to oxidative stress.
Julien Verrax,Raphaël Beck,Nicolas Dejeans,Christophe Glorieux,Brice Sid,Rozangela Curi Pedrosa,Julio Benites,David Vásquez,Jaime A. Valderrama,Pedro Buc Calderon +9 more
TL;DR: A new strategy based on the use of pharmacologic concentrations of ascorbate and redox-active quinones is developed, which could represent an original approach that could be combined to standard cancer therapy.
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