Ranran Li

TL;DR: It is revealed that AMPK activation-mediated HDAC5 phosphorylation and KLF2 restoration is, at least partially, responsible to the anti-inflammatory effects of metformin in endotoxemia-induced endothelial cells, which has important implications for the future development of interfering therapies of sepsis.

TL;DR: Investigating the role of key glycolytic enzyme PFKFB3 in tumor necrosis factor-α (TNF-α)-induced endothelial proinflammatory responses found that TNF- α increased endothelial PKFB3 expression, and inhibition of PFK FB3 inhibited T NF-α-induced Ikkβ phosphorylation, IκBα phosphorylated and degradation, NF-κB-p65 phosphorylations, nuclear translocation, and DNA-binding

TL;DR: Systemic reactivation of Epstein–Barr virus (EBV) may occur in novel coronavirus disease 2019 (COVID‐19) caused by the severe acute respiratory syndrome coronvirus‐2 (SARS‐CoV‐2) but the clinical consequences remain uncertain.

TL;DR: The authors showed that phenylalanine promoted pyroptosis of AMs, which exacerbated lung inflammation and ARDS lethality in mice and initiated the NLRP3 pathway by activating the calcium-sensing receptor (CaSR).